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Trivia: Since the movie takes place around Halloween, during the subway scene, you can see random people dressed up in costumes as various horror movie characters and monsters. In at least one shot, you can also see a woman in the background dressed up as Grace from the movie "Ready or Not." "Ready or Not" and "Scream VI" were made by the same producing and directing team. Additionally, Samara Weaving, who played Grace in "Ready or Not," has a cameo in the movie as a film studies professor.

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Trivia: When Gale and Sam are talking at the theater and are referencing making a new family even after losing someone they care for, in the background you can faintly hear Dewey's theme from the previous films.

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Trivia: The first film in the series in which Ghostface uses a gun while still masked. Up until this film, it was an "unwritten rule" in the series that while masked, Ghostface would only use classic slasher weapons like knives, or the environment around him to kill. Ghostface would only be allowed to use guns when unmasked. The directors decided to break this rule in order to make Ghostface feel like a bigger, much more realistic threat than ever before... he'd break his own rules to get his targets.

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Trivia: With this film, Courteney Cox (Gale Weathers) and Roger L. Jackson (the voice of "Ghostface") are the only actors to be in every "Scream" movie.

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Trivia: The first credited acting role for Hayden Panettiere in five years. Panettiere had taken a four-year hiatus from acting starting in 2018 to work on her physical and mental health after a series of personal issues. When she found out the "Scream" franchise was being brought back in 2022, she called the directors and pitched the idea that her character Kirby could return in a future installment. While her cameo in that film was cut, the directors promised she'd be back for the sixth film.

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Trivia: The opening scene at the evidence depository that shows things like Michael Myers' mask and Freddy Krueger's glove was originally written for "Child's Play 2," which was meant to open with a courtroom scene. The scene would have shown Chucky's remains being collected and taken to court. However, the scene was cut. Series creator and writer Don Mancini really loved the idea of an evidence locker full of references to other horror movies, so he reused it as the opening scene for this film.

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Trivia: MAJOR SPOILERS: Courtney Cox was heartbroken when she read the script and saw that Dewey got killed off, since he was such a likeable, positive character. She tried to talk the directors out of actually killing him by throwing in a last-minute twist that he was still alive, such as her getting a text from him at the hospital and revealing he wasn't the one in the body-bag. However, she ultimately agreed with their decision to kill him off, since it raised the stakes.

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Trivia: The final feature-film to feature Luke Perry, who tragically passed away a few months before its release after suffering two strokes.

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Trivia: SPOILER: There's a "blink and you'll miss it" clue to one of the killer's identities. When they discover Randy's body, there's a quick shot of his bloody hand. Among the smears of blood, you can also very briefly see a distinct red lipstick mark on his hand. It's similar to the lipstick shade Debbie Salt wears in a few scenes. Debbie is later revealed to be one of the killers, and mentions that she killed Randy. (Presumably he got her lipstick on his hand while they were struggling).

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Trivia: Gale's cameraman Joel leaving was actually an idea actor Duane Martin had. He pitched the idea to Wes Craven, saying that there's no way his character would actually stick around once the bodies started piling up. Craven asked him how he'd leave, and Martin replied that he'd "take a cab." Craven found this idea so funny that he actually worked it into the film, and also added the moment where Joel returns at the very end once the killers were dead.

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Trivia: Various endings were considered, including one where almost all the protagonists die, and an ending where it is revealed that there was another killer whose identity we never discover.

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Trivia: The film's title was originally "Scream: The Sequel" during filming. Other titles considered included "Scream Louder" and "Scream Again." Eventually, they settled on the simplest title: "Scream 2."

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Trivia: Originally, the ending was a bit different. Sidney's battle with Roman was shorter, with Sidney being more savage and easily killing him due to her trauma making her fight harder. Detective Kincaid was also absent. The studio felt that the ending was anticlimactic, and requested that it be reshot to show Sidney struggling more, and to give her a fake-out "death" to raise the stakes. They also added Kincaid to the final battle and last scene since they felt his character needed resolution.

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Trivia: The first "Scream" film not released around Christmas. It was meant to be released in December, 1999, but had to be delayed by two months due to reshoots.

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Trivia: Due to scheduling and casting issues, Patrick Dempsey was reportedly hired the night before he began filming and had to stay up most of the night trying to memorize lines for his first day.

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Trivia: When the film was released on home-video, it shattered the previous record and became the fastest-selling DVD ever, with 2 million units sold in its first week of release. This is actually a significant achievement, as DVD was still in the early stages of taking over, and more people bought VHS tapes than DVD's in 2001. Unfortunately, this record was very short-lived... it was surpassed by "Star Wars: Episode I - The Phantom Menace" only two weeks later, which beat it with 2.2 million units.

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Trivia: The film's title is derived from the 1963 song of the same name. Ironically, even though the song was featured in the movie's trailers, it wasn't featured in the film itself. Additionally, the title is a bit of a misnomer, as the two romantic leads weren't in a relationship until the very end of the film, so Johnny wasn't technically Missy's boyfriend when he came back from the grave.

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Trivia: This comedy features several future stars. It was the feature film debut of Matthew Fox of "Lost" fame and superstar Matthew McConaughey (albeit in a very small role). It's one of Philip Seymour Hoffman's earliest movies. And it would have also been Renée Zellweger's feature film debut, but her scene was cut before release.

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Trivia: Director Christophe Gans intended to make a sequel, but stepped away due to other commitments. He also disagreed with the producers over the direction of the sequel. The 2012 sequel "Silent Hill: Revelation" was released to poor reception and effectively ended the series. However, 16 years after this film, Gans confirmed that he was finally returning to the franchise with a new film, "Return to Silent Hill," that would serve as a soft reboot and adapt the fan-favorite game "Silent Hill 2."

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Trivia: There are several subtle references to the 2018 film "Searching" in this movie. Most notably, the stock-photo model Hannah from "Searching" is briefly seen in this film in a thumbnail image for a YouTube video. Director Aneesh Chaganty has stated that this was intentional, and that "Searching," "Run" and by extension, "Missing" (the semi-sequel to "Searching") are all set within the same cinematic universe.

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