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Trivia: Early on in production, director Wes Craven knew he wanted the character Randy Meeks to appear to explain the rules of a trilogy. He briefly contemplated a reveal that Randy survived his apparent death in "Scream 2" and had gone into hiding, but decided that this would undermine the high stakes of the series. He instead settled on the idea of Randy having made a video-tape about the rules shortly before his death.

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Trivia: When Johnny takes Missy to the movie theater, in one of the comic panels we see the name of the movie they're seeing is "Johnny Zombie." This was actually the original title of this film before it was changed to "My Boyfriend's Back."

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Trivia: Reportedly, Aunt May was not featured in the show as a character (only being seen in photographs) because MTV feared her inclusion would make teenagers and 20-somethings less likely to watch for... some reason.

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Trivia: The first film Wes Craven both wrote and directed since the release of "New Nightmare" 16 years earlier. It was also the final film Craven both wrote and directed before he tragically passed away. (While he did direct "Scream 4" the following year, he was not a credited writer on it).

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Trivia: Peter's ringtone is the classic Nokia ringtone, but played in reverse.

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Trivia: Kingpin is voiced by Michael Clarke Duncan, who also played him in the live-action 2003 "Daredevil" movie.

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Trivia: Originally intended to be a stand-alone series that adapted the "Ultimate Spider-Man" comics. However, it was retooled slightly during pre-production to also serve as a sort-of tie-in to the popular 2002 "Spider-Man" movie by incorporating elements from it, down to even using a slightly modified version of the movie's title card font for the opening credits. However, the show was later rendered non-canonical due to the movie sequels contradicting it.

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Season 2 generally

Trivia: Something for the film score geeks - In season two, episode five, when Tiffany reveals the original Glen doll to the human version of Glen, for about thirty seconds in the background, you can faintly hear a new recording of the theme to "Seed of Chucky," the film where Glen/Glenda was first introduced. Later, in episode eight, when "G.G." is revealed in doll form, we again hear snippets of a new recording from the "Seed of Chucky" score. (Taken from the ending of the track "Pride of Chucky").

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Trivia: The show was actually a ratings hit for MTV, who distributed it. However, despite its popularity, the network decided to cancel it as network executives felt it didn't quite fit in with their other content. Sadly, this meant the show ended on a cliffhanger.

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Trivia: The bodega in the film is called "Abe's Snake Bodega." This is a deep cut reference to original "Scream" director Wes Craven. In the early-to-mid 1970's, Craven worked as a crew member on several pornographic films to make ends meet, and he used the name "Abe Snake" as a pseudonym.

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Trivia: The directors studied "Friday the 13th Part VIII: Jason Takes Manhattan" during pre-production to figure out what they could do to avoid running into similar issues, as that film is widely disliked for failing to take advantage of its New York City setting. The directors jokingly said their biggest takeaway from that film was that they "wanted to make sure that we didn't have a boat in this!" (That film notoriously is mostly set on a boat, with only the final 20 minutes being in New York).

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Trivia: Since the movie takes place around Halloween, during the subway scene, you can see random people dressed up in costumes as various horror movie characters and monsters. In at least one shot, you can also see a woman in the background dressed up as Grace from the movie "Ready or Not." "Ready or Not" and "Scream VI" were made by the same producing and directing team. Additionally, Samara Weaving, who played Grace in "Ready or Not," has a cameo in the movie as a film studies professor.

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Trivia: When Gale and Sam are talking at the theater and are referencing making a new family even after losing someone they care for, in the background you can faintly hear Dewey's theme from the previous films.

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Trivia: The first film in the series in which Ghostface uses a gun while still masked. Up until this film, it was an "unwritten rule" in the series that while masked, Ghostface would only use classic slasher weapons like knives, or the environment around him to kill. Ghostface would only be allowed to use guns when unmasked. The directors decided to break this rule in order to make Ghostface feel like a bigger, much more realistic threat than ever before... he'd break his own rules to get his targets.

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Trivia: With this film, Courteney Cox (Gale Weathers) and Roger L. Jackson (the voice of "Ghostface") are the only actors to be in every "Scream" movie.

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Trivia: The first credited acting role for Hayden Panettiere in five years. Panettiere had taken a four-year hiatus from acting starting in 2018 to work on her physical and mental health after a series of personal issues. When she found out the "Scream" franchise was being brought back in 2022, she called the directors and pitched the idea that her character Kirby could return in a future installment. While her cameo in that film was cut, the directors promised she'd be back for the sixth film.

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Trivia: The opening scene at the evidence depository that shows things like Michael Myers' mask and Freddy Krueger's glove was originally written for "Child's Play 2," which was meant to open with a courtroom scene. The scene would have shown Chucky's remains being collected and taken to court. However, the scene was cut. Series creator and writer Don Mancini really loved the idea of an evidence locker full of references to other horror movies, so he reused it as the opening scene for this film.

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Trivia: MAJOR SPOILERS: Courtney Cox was heartbroken when she read the script and saw that Dewey got killed off, since he was such a likeable, positive character. She tried to talk the directors out of actually killing him by throwing in a last-minute twist that he was still alive, such as her getting a text from him at the hospital and revealing he wasn't the one in the body-bag. However, she ultimately agreed with their decision to kill him off, since it raised the stakes.

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Trivia: The final feature-film to feature Luke Perry, who tragically passed away a few months before its release after suffering two strokes.

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Trivia: SPOILER: There's a "blink and you'll miss it" clue to one of the killer's identities. When they discover Randy's body, there's a quick shot of his bloody hand. Among the smears of blood, you can also very briefly see a distinct red lipstick mark on his hand. It's similar to the lipstick shade Debbie Salt wears in a few scenes. Debbie is later revealed to be one of the killers, and mentions that she killed Randy. (Presumably he got her lipstick on his hand while they were struggling).

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