Continuity mistake: When Sheldon is looking at his socks that Penny paired up, his grip on them changes between shots. (00:06:00)
Continuity mistake: Penny throws Sheldon's sock down on the table, and their positions change when Sheldon picks them up, despite no one touching them. (00:05:50)
The Griffin Equivalency - S2-E4
Continuity mistake: When talking to his parents, Raj's grip on the laptop changes between shots. Note the side of the screen. (00:18:10)
The Barbarian Sublimation - S2-E3
Continuity mistake: When Penny is talking to Sheldon in his bedroom, her hands are constantly changing positions between shots. (00:08:45)
Continuity mistake: Leonard says that Sheldon has gone crazy and chucks his pen down on a red pad on the desk. When the shot changes, so does the position of the pen without being touched. (00:13:10)
The Cooper-Nowitzki Theorem - S2-E6
Continuity mistake: When Raj says there is always a catch, Leonard's hand goes from on the table to on his leg between camera cuts. (00:03:00)
Continuity mistake: When Leonard shows Penny the leaflet at the end, she is holding it in one hand in shot but with 2 as the camera changes. (00:19:50)
Continuity mistake: In the laundry room, Sheldon is holding a blue shirt in his hands and has a bit of extra material near his hands. When the shot changes, he is holding the shirt differently and the extra material has gone. (00:05:50)
The Habitation Configuration - S6-E7
Continuity mistake: When Howard is almost done moving out of his mother's house, there is a table in front of him with a measuring device in the top corner. In one shot, the device moves to the opposite corner of the table. In a few shots later, the item returns to its original position.
The Separation Oscillation - S9-E2
Continuity mistake: Sheldon is returning Amy's scarf and says, "You wore it the night we went ice skating, remember?" to which Amy replies, "You mean the night that I went ice skating and you stood at the rail Googling the symptoms of hypothermia." But in episode 8-12: The Space Probe Disintegration, Amy states that she cannot go ice skating because she has "unnaturally brittle ankles." (00:04:55)
The First Pitch Insufficiency - S8-E3
Continuity mistake: When Howard is on the mound, the shot from behind the plate shows a player ready to catch the ball in a uniform shirt. The next long shot from the stands shows a catcher in full gear, and then back to behind the plate to the player in uniform shirt only.
The Discovery Dissipation - S7-E10
Continuity mistake: The Stevenson Award in Sheldon's office reads "Sheldon Cooper, PhD." But, in the "Dennis Kim" episode we are told Sheldon was 14.5 years old when he earned that award - 1.5 years before earning his PhD at age 16, so the award should not show the title of PhD.
The Skank Reflex Analysis - S5-E1
Continuity mistake: At the start of the episode, Raj's Sirkist can rotates itself on the table.
The Fuzzy Boots Corollary - S1-E3
Continuity mistake: When Sheldon is telling Leonard that he didn't ask Penny out, there is a yellow food-bag on the counter between them that keeps changing its position with every shot change. (00:11:15)
The Hamburger Postulate - S1-E5
Continuity mistake: At the end when Sheldon has got a burger, the amount of burger left changes depending on the camera angle. Most noticeable when he asks Penny about permanently reserving the table - between shots the lettuce disappears, the bun changes colour, and the bite marks change.
The Boyfriend Complexity - S4-E9
Continuity mistake: In 2-15 "The Maternal Capacitance" Penny explains to Beverly, referring to her father, "My mom could have just said 'Bob, get over it, she's a girl'". But in this episode Penny's father is named Wyatt.
Continuity mistake: In the laundry room when Penny is talking to Sheldon, Sheldon takes some time arranging a blue shirt on his plastic laundry folder. Then it suddenly turns into a pair of socks, which he folds and then picks up the blue shirt again. There was not enough time for him to switch out the shirt for the socks. (00:06:30)
The Long Distance Dissonance - S10-E24
Continuity mistake: After the 'Ramona' conversation between Sheldon and Penny ends, Sheldon leaves Penny alone on the couch. Penny looks up to the "Amy and Penny" painting and says "Don't look at me like that, I tried." In S10 E10, Amy gave the painting back to Penny, which was hung in Leonard's living room.
Continuity mistake: Penny throws a black iPod out the window, but when Raj comes in having found it on the ground outside he has a silver one. (00:01:00 - 00:02:45)
The Agreement Dissection - S4-E21
Continuity mistake: When the girls take Sheldon out dancing, he mentions that he considers himself a proficient dancer due to his Cotillion training when he was a boy. But in S1E7 The Dumpling Paradox, when Leonard suggests that they could have gone dancing with the girls, Sheldon said that nobody in the group - including him - could dance.
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.