The Extract Obliteration - S6-E6
Stephen Hawking: Do you like brain teasers?
Sheldon Cooper: Oh, I love brain teasers.
Stephen Hawking: What do Sheldon Cooper and a black hole have in common? They both suck. Neener, neener.
The Staircase Implementation - S3-E22
Leonard: Oh, screw the roommate agreement!
Sheldon: No, you don't screw the roommate agreement! The roommate agreement screws you!
The Big Bran Hypothesis - S1-E2
Sheldon: Oh Gravity, thou art a heartless bitch.
The Desperation Emanation - S4-E5
Leonard: What about you, Stuart? You have a girlfriend yet?
Stuart: Oh, yeah. Yeah. I met her at Comic-Con, the one place in the world where saying I own a comic book store is an actual pickup line.
The Bat Jar Conjecture - S1-E13
Sheldon: At this point, I should inform you that I intend to form my own team and destroy the very bonds that bind your very matter together and reduce the resulting particulate chaos to tears!
Leonard: Thanks for the heads up.
Sheldon: You're welcome. [Turns to leave.] One more thing,
Leonard: Yes?
Sheldon: It's on, bitch.
The Convention Conundrum - S7-E14
Sheldon Cooper: [sneaking up to a house] I don't understand what we're doing.
James Earl Jones: Shhhh!
Sheldon Cooper: Whose house is this?
James Earl Jones: Carrie Fisher. And she's a little crazy, so get ready to run.
[He rings the doorbell, and they run for it.]
Carrie Fisher: [storms out with a baseball bat] It's not funny anymore, James!
James Earl Jones: Then why am I laughing?
The Lizard-Spock Expansion - S2-E8
Sheldon: What happened?
Leonard: Howard's at the Mars Rover lab. He says he's in trouble. Defcon 5.
Sheldon: Defcon 5? Well, there's no need to rush.
Leonard: What?
Sheldon: Defcon 5 means no danger. Defcon 1 is a crisis.
Leonard: How can 5 not be worse than 1?
Raj: Yeah, Star Trek V, worse than I.
Sheldon: Okay, first of all, that's a comparison of quality, not intensity. Secondly, Star Trek I is orders-of-magnitude worse than Star Trek V.
Raj: Are you joking? Star Trek V is the standard against which all badness is measured.
Sheldon: No, no, no. Star Trek V has specific failures in writing and direction, while Star Trek I fails across the board, art direction, costuming, music, sound editing.
Leonard: Can we just forget I said Defcon and go?
Raj: Star Trek V!
Sheldon: All right, will you at least stipulate that Star Trek IV: The Voyage Home is in-arguably the best?
Raj: I have three words for you. Wrath of Khan.
The Lizard-Spock Expansion - S2-E8
Sheldon: I'm sorry, but I'm not going to watch the Clone Wars TV series until I've seen the Clone Wars movie. I prefer to let George Lucas disappoint me in the order he intended.
The Agreement Dissection - S4-E21
Sheldon: You may have gone to Cambridge, but I am an honorary graduate of Starfleet Academy.
Sheldon: Every Saturday morning since we've lived in this apartment, I have awakened at 6:15, poured myself a bowl of cereal, added a quarter cup of 2% milk, sat on that end of that couch, turned on BBC America and watched Doctor Who.
Leonard: Penny's still sleeping.
[Sheldon stares at Penny for some time.]
Sheldon: Every Saturday since we've lived in this apartment.
The White Asparagus Triangulation - S2-E9
[Sheldon points to a computer.]
Sheldon: Tell me what you see here.
Leonard: The blunt instrument that will be the focus of my murder trial?
Sheldon: You participate in the mass cultural delusion that the sun's apparent position relative to arbitrarily defined constellations at the time of your birth somehow effects your personality.
Sheldon: I'm not crazy. My mother had me tested.
The Lizard-Spock Expansion - S2-E8
Howard Wolowitz: If it's "creepy" to use the Internet, military satellites, and robot aircraft to find a house full of gorgeous young models so I can drop in on them unexpected, then FINE, I'm "creepy."
The Vacation Solution - S5-E16
Howard: I'm not signing a pre-nup.
Penny: Alright, Howard Wolowitz, listen up. You sign anything she puts in front of you because you are the luckiest man alive. If you let her go, there is no way you will be able to find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting!
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.