The Long Distance Dissonance - S10-E24
Continuity mistake: After the 'Ramona' conversation between Sheldon and Penny ends, Sheldon leaves Penny alone on the couch. Penny looks up to the "Amy and Penny" painting and says "Don't look at me like that, I tried." In S10 E10, Amy gave the painting back to Penny, which was hung in Leonard's living room.
The Long Distance Dissonance - S10-E24
Continuity mistake: When Sheldon takes a plane to see Amy in Princeton, the plane he is on has 2 engines when it takes off and 4 engines when it lands. It's a direct flight from LAX so he wouldn't have changed planes.
The Recollection Dissipation - S10-E20
Continuity mistake: When Howard and Bernadette are talking in the kitchen by themselves, Howard's bottle of water keeps moving between shots.
The Escape Hatch Identification - S10-E18
Continuity mistake: Stewart eats a ham sandwich when he and Raj are talking alone in Howard's and Bernadette's living room. On at least one occasion the sandwich's size gets larger, not smaller between bites as Stewart is eating it.
The Fetal Kick Catalyst - S10-E6
Continuity mistake: Near the end of the episode where Sheldon and Stuart are drunk and talking about how Sheldon never leaves the house without a paperclip, the amount of Mimosa in their glasses suddenly decreases between shots.
The Brain Bowl Incubation - S10-E8
Continuity mistake: When Raj puts down the rubber gloves when talking with Isabella, the gloves completely vanish 6 shots later with nobody touching them.
The Dependence Transcendence - S10-E3
Continuity mistake: Bernadette is talking to Raj's dad on the video phone. In the close up, her fingers are wrapped round the phone but in the long shot, she is holding her fingers behind it and balancing it with her thumb.
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.