The Russian Rocket Reaction - S5-E5
Continuity mistake: In the scene where Howard and Bernadette are about to have sex and Bernadette leaves to "brush her teeth", Howard stretches and lays on the bed uncovered. After Howard's mother yells "over my dead body my son goes to space" and Bernadette appears again and says "I'm ready", then it flashes back to Howard and he is instantly covered up.
The Precious Fragmentation - S3-E17
Continuity mistake: When Sheldon sneaks into Leonard's bedroom while Leonard and Penny are sleeping, Penny has her arms out over the blanket and Leonard has his on his pillow in front of his face. When Sheldon leans over Penny only her hands are on top of the covers and Leonard's are tucked under his pillow.
Continuity mistake: When Penny is talking to Leonard about who read her Ex's blog, she has a spoon full of ice-cream. Camera cuts and it's now empty. (00:05:00)
The Prestidigitation Approximation - S4-E18
Continuity mistake: It is well-known that Leonard's glasses do not have lenses to avoid catching reflection by the lights. In this episode, Priya takes Leonard's glasses off, and they have lenses.
The Extract Obliteration - S6-E6
Continuity mistake: Sheldon is siting at the kitchen counter with a mug in front of him. In one shot, the string of a teabag appears coming out of the mug. In between shots, the teabag string moves by itself.
The Robotic Manipulation - S4-E1
Continuity mistake: At the start, as Howard says "And finally my kung pow chicken" the robot arm is level with the top of the bag. Camera cuts and it's reaching to the bottom of the bag. (00:00:15)
The Classified Materials Turbulence - S2-E22
Continuity mistake: Leonard is talking to Stuart at the door to his (Leonard's) apartment. Howard then comes over and slams the door in Stuart's face and Leonard has moved back about 4-ft instantly.
The Lizard-Spock Expansion - S2-E8
Continuity mistake: The way Leonard holds the can of Diet coke before he puts it down changes between shots. (00:00:25)
The Matrimonial Momentum - S9-E1
Continuity mistake: In the first half of the episode while in Las Vegas, Penny's hair is short; however, later in the episode when she is back in the apartment speaking with Sheldon, her hair is much longer, albeit tied back in a bun, but very obviously much longer and a very different color. The scene from Las Vegas to her apartment was less than 24 hours apart and would have been impossible for her hair to have grown so much.
The Hot Troll Deviation - S4-E4
Continuity mistake: When Sheldon and Raj are arguing about having a desk in Sheldon's office, Sheldon's bottle of water keeps rotating without anyone touching it - take note of the label. The level of water in Sheldon's drink also keeps changing between shots. (00:06:20)
The Robotic Manipulation - S4-E1
Continuity mistake: When driving to the date, the cars behind Penny's change place instantly. For example a 4x4 becomes 3 cars, which become 1 car in the space of 3 seconds. (00:09:10)
The Bath Item Gift Hypothesis - S2-E11
Continuity mistake: When Penny takes a drink from the egg-nog carton before kissing Leonard on the cheek, between shots the logo-branded label changes which direction it faces in her hand. (00:16:45)
The Vartabedian Conundrum - S2-E10
Continuity mistake: When Stephanie asks Leonard why he hasn't told her about Penny, he spills some of the pancake mixture out of the bowl he is stirring. In some shots the spilled mixture vanishes and the appears again.
The Maternal Capacitance - S2-E15
Continuity mistake: After Leonard's mother says, 'Tell me about it', her head was tilted downwards, but in the next shot, she was looking straight again. (00:04:35)
The Vartabedian Conundrum - S2-E10
Continuity mistake: When Leonard, Raj and Howard are talking about Leonard's new trousers, the items on the tray behind Howard keep changing.
The Einstein Approximation - S3-E14
Continuity mistake: When Sheldon is playing in the ball pit and Leonard is trying to coax him out the position of the black netting of the ball pit alternates between being and not being wrapped around the yellow entrance pillars.
The Classified Materials Turbulence - S2-E22
Continuity mistake: When Raj is going through the ideas on what would work to fix the toilet, Sheldon's hand is not near his face, but when Howard talks about moving to Israel, Sheldon's hand is up by his face.
The Grasshopper Experiment - S1-E8
Continuity mistake: When Raj starts talking to Penny after he drinks the Grasshopper drink in her apartment, in one frontal shot he lifts the drink and begins to drink but in the next shot from behind the drink is back on the counter.
The Monopolar Expedition - S2-E23
Continuity mistake: When Penny finds out about the expedition, Sheldon starts to walk to his apartment. Camera cuts to Leonard in the apartment for five seconds and then to Penny in the doorway. Behind her, you can see Sheldon walking to the apartment still. Since he was halfway to start with, he should be in the apartment by now. (00:10:35)
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.