Herpe, the Love Sore - S12-E16
Factual error: Stewie could not have gotten herpes by blood - it's only transmitted by infected saliva or skin.
Suggested correction: Please tell me that you are not a doctor! The two types of herpes viruses, HSV1 and HSV2 can be transmitted in blood as well as saliva. Such transmission is very rare as the virus deactivates rapidly in stored blood, but it is incorrect to say that it cannot happen.
The Cleveland-Loretta Quagmire - S4-E5
Plot hole: Brian and Peter see Loretta and Quagmire having sex yet, they aren't sure who she's having an affair with. There's no way they couldn't have noticed it was Quagmire - the couch was facing the front door! And obviously Quagmire was on top of Loretta considering the fact that he leans up, says something, then she tells him to get back down here and finish.
Continuity mistake: When Bertram sneaks into Stewie's bedroom, he tiptoes past Stewie, who is sleeping. But in the next close-up of Bertram, the shot pulls back and pans the room so we see Stewie's crib is empty. But in the next shot, Stewie is still sleeping, and then he wakes up. (00:10:25)
The Tan Aquatic with Steve Zissou - S5-E11
Continuity mistake: When Peter attacks Kyle, his shirt is clear of blood. However, when the shot changes to an overhead one, blood has suddenly appeared on his shirt. (00:09:50)
The Courtship of Stewie's Father - S4-E16
Continuity mistake: After Peter and Stewie's Jungle Cruise ride, when Michael Eisner walks up to the duo, Eisner's suit buttons are on his left, but then the buttons switch to the opposite side, and his tie's stripes change direction as well. (00:19:50)
The Courtship of Stewie's Father - S4-E16
Continuity mistake: When Peter takes the garden hose upstairs, the bathroom doorknob is on the right side. As Peter kicks in the door, but from inside the bathroom, the doorknob is on the opposite side of the door, so it swings open the opposite way. (00:10:25)
The Courtship of Stewie's Father - S4-E16
Continuity mistake: After Peter's mess of glee club, in the first shot of Obi-Wan the right side of his robe is over his left side, but next shot it's the opposite way with the left side over the right. (00:02:15)
Brian Goes Back to College - S4-E15
Continuity mistake: After painting the stripe on the van, the side passenger door handle vanishes when Peter/Hannibal gets into the front seat; then, that handle reappears when Quagmire/Face enters the van. (00:09:10)
Brian Goes Back to College - S4-E15
Continuity mistake: When Brian is escorted into the New Yorker's writers' lounge, the door has a knob and backplate, but the backplate vanishes in a following shot. (00:03:15)
Brian Goes Back to College - S4-E15
Continuity mistake: After the opening credits, Peter/Hannibal is wearing a jacket with pockets only on his right side; then pockets suddenly appear on his left side between shots. (00:00:40)
Continuity mistake: When Bertram climbs through the window into Stewie's bedroom, just as he tiptoes past a sleeping Stewie, the lightswitch on the wall is in the up position and the room is dark, but two shots later Stewie wakes up and now the lightswitch is in the down position so Stewie flips it up, then the light turns on. (00:10:20)
Chick Cancer - S5-E7
Continuity mistake: When we see the banner saying "Happy Birthday Quinn!", the I is next to the U. However, in the close-up there is a sizeable gap between them. (00:12:50)
Continuity mistake: When Joe and all the handicapped meet in front of Peter's restaurant, Joe is by some white lines in one shot and not in the next. (00:16:30)
Continuity mistake: When Peter is hiding in the bedroom, the colour of the books by the TV change between shots. Most noticeable is 2 blue books become 1. (00:06:00)
Continuity mistake: When Meg is talking about getting a job and buying a car, Stewie goes from reading a book to reading a newspaper. (00:09:20)
Continuity mistake: The rug in the living room vanishes when Peter walks across and sits down. (00:04:00)
Continuity mistake: When Peter comes home from work, the position of the rug moves in relation to the sofa. Note Chris' feet. (00:03:50)
Airport '07 - S5-E12
Continuity mistake: When Peter hits Quagmire's car, his truck leaves grey marks across the grass. When we get the close-up of people escaping, the marks on the floor have disappeared. (00:04:10)
Airport '07 - S5-E12
Continuity mistake: Peter puts the spray paint on the driveway. After the close-up of the truck window, they are now on the grass. (00:03:50)
The Tan Aquatic with Steve Zissou - S5-E11
Continuity mistake: When Chris holds out the newspaper for Herbert, it has a very noticeable band around it in the long shot, which changes in appearance in a closer shot. (00:02:10)