Continuity mistake: Enter The Cheatrix: When Bart and Lisa knock on Frink's door, they receive no answer and smash the window basement down and enter the basement. As the window smashes, part of the wooden window frame falls out of the frame and lands on the floor. Next shot, the glass from the broken window is still on the ground for a split second, but no wooden frame.
Bug: Maggie has an ability where she can crawl through ventilation systems and turn on a switch by spitting her pacifier at it. If not directly facing the switch, the pacifier may miss the switch by an inch or two, but the switch will still get turned on anyways.
Bug: Mob Rules: On the Wii version, after destroying the billboard on construction site, (the one after Grandpa Simpson becomes part of the mob), all of the debris will pass through the ground when it collapses.
Audio problem: In the hallway in the Simpson household, a grandfather is heard ticking, but the pendulum never moves along with each tick.
Bug: If the player puts Bart in the living room, and Marge walks into the room and exits, she will walk into the wall before exiting and keep trying to walk for a few seconds.
Bug: Lisa The Tree Hugger: When Lisa is jumping through the animals and logs in the water, if she misses a jump and begins to fall into the water, a bug might occur where she ends up back at the starting point. A jump onto a turtle. After missing, instead of ending up in the water, she might end up back where she started.
Bug: Lisa The Tree Hugger: At one point, Lisa will have to use her Buddha hand ability to place three waste buckets onto a conveyor belt. After two of those buckets go in, the machine that the conveyor belt leads to will explode. The third one will remain on the conveyor belt but will disappear when it reaches the destroyed machine.
Continuity mistake: Around the World in 80 Bites: Just after Homer takes down the last part of the "Statue of Liberty", in the cutscene that follows, Homer has disappeared from in front of it.
Other mistake: Around The World In 80 Bites: On the Wii and PSP versions, once Homer and Bart make it into America, only two or three of the other people in the race still come inside America. The other contestants just continue to run around Italy, not even proceeding to the next part.
Factual error: Around The World In 80 Bites: The race track depicts Stonehenge as located in Scotland, when it is in fact located in Wiltshire, England.
Other mistake: Bartman Begins: When Bart drops the huge dinosaur skeleton on top of Dolph, Dolph is still shown standing despite the huge skeleton landing on top of him. His body also passes through one of the ribs.
Continuity mistake: Whenever Bart fires his slingshot, we can see the stone he used fall on the ground. The stone disappears off the ground about 5 seconds later.
Bug: Try and walk around the car in the Simpson garage from the right. After walking past the boot, it won't let you walk around the left side of the car.
Character mistake: In the Simpson house, the time on the grandfather clock in the hallway reads 12:15. But the clock in the kitchen reads 10:00.
Continuity mistake: The Land of Chocolate: Homer is taller than the White Chocolate Rabbit in the opening cutscene. But in the level, the White Chocolate Rabbit is taller than Homer.
Other mistake: The Land of Chocolate: Homer starts off in The Land of Chocolate with the Population sign behind him. Homer then runs about 40 yards and runs into the village of Fudgetown. When the level starts, if you go the wrong way from what you are supposed to, you can see the Land of Chocolate population sign only a couple of yards away from where you start.
Audio problem: On several occasions, characters will say random lines during the gameplay sections of levels. Sometimes characters will say the lines, but their mouths never move whilst saying it.
Continuity mistake: The Land of Chocolate: The bite mark from the lamp post Homer takes a bite from in the opening cutscene disappears when the level starts.
Continuity mistake: Game Over: When Lisa runs outside, Homer and Marge walk up to the door to tell her it's not safe. The hallway behind appears brightly lit in this shot. It then cuts to Lisa telling them her plan and when it cuts back to Homer and Marge, the hallway behind them is much more dimly lit.
Revealing mistake: Bargain Bin: When the family run outside to see the mothership flying over their house, they stand on the front doorstep. Homer and Bart's left foot can be seen unnaturally overlapping with the vertical side of the step.
