Audio problem: Game Over: After Marge says all that's left to do is hope God saves us, Lisa says "That's it, mom." When she finishes the line, her teeth clench together, but there are no words or letters in the line that would have made her teeth clench together in the way that was shown. Clearly the wrong mouth movement was used in the animation.
Audio problem: Game Over: After God says he will grant all the Simpsons' requests, Lisa says "God. There is one thing." When she says "God", her mouth appears to close a split second before finishing the name.
Audio problem: Game Over: When God is asking the Simpsons what they want, Marge says "Put Springfield back the way it was." When she finishes the line, she makes an O shape with her mouth as if she is about to say something, but no additional dialogue is heard coming out.
Audio problem: Mob Rules: After Mayor Quimby bans Grand Theft Scratchy for minors, the mob is heard cheering, but none of their lips are moving with the cheers.
Audio problem: Mob Rules: When the Simpsons are at the breakfast table talking about their powers, Homer says "That was the greatest day of my life", but his mouth is both out-of-sync when he is speaking the second half of the line and his mouth also stops moving before he finishes.
Audio problem: Bargain Bin: When the mothership fires on the Simpsons, they are heard screaming, but their mouths are closed and not moving.
Audio problem: Grand Theft Scratchy: As Marge apologises to Poochie, she says "Sorry, Poochie. But even you aren't extreme enough to resist the power of a stay at home mom with too much time in her hands." Lisa then replies "Yeah!" If you look closely, you can see Lisa says "Yeah" before her lips even move.
Audio problem: Bargain Bin: When Homer asks "You like doughnuts too?" to 8-bit Homer, the poorly rendered Homer mouths the word "too" as well, but nothing is heard.
Audio problem: Bargain Bin: Just after Homer and Bart save the 8-bit Simpsons, Homer and Bart run into the elevator. Will Wright then says "Who put you up to this? Was it those jerks at EA? They're jealous of me, you know?" His mouth reads something totally different when he says this.
Audio problem: In the hallway in the Simpson household, a grandfather is heard ticking, but the pendulum never moves along with each tick.
Audio problem: On several occasions, characters will say random lines during the gameplay sections of levels. Sometimes characters will say the lines, but their mouths never move whilst saying it.
Audio problem: Bartman Begins: Right before Bart goes to lean down to pick up the manual off the ground, he says "This is so weird." When he finishes the line, his mouth can be seen making a circular shape from when he said the R in "weird", however this wouldn't have been possible as the line would have ended with a D, meaning his lips should have been stretched and not making the circular shape that was shown.
