Continuity mistake: Raj talks in front of Penny near the beginning of the episode, then picks up dishes, walks toward the kitchen, and just disappears from the set.
Suggested correction: Couple of points here, 1. Raj talking in front of Penny is already listed. 2. Raj doesn't pick the plates up until Penny has left after the Halo game. 3. He then stays in the kitchen area while we see Penny come back and settle down to go to sleep and Leonard and Sheldon go to bed and turn the lights out. Raj then creeps out the apartment and scares Penny.
The Grasshopper Experiment - S1-E8
Continuity mistake: When Raj's parents tell him to put his laptop down and gather his friends, they all huddle around the one-seat sofa. Sheldon is crouched to the left of the seat with his hands on the sidearm, yet in shots angled at the left he has disappeared from his place (as to not obstruct these particular angled shots.) (00:02:00)
The Grasshopper Experiment - S1-E8
Deliberate mistake: At the end, Penny holds up a bottle of rum to show Leonard that she added it to his drink. However, the B is missing from the name "Bacardi" (00:19:30)
The Grasshopper Experiment - S1-E8
Continuity mistake: When Raj is drinking with Lalita in the bar Penny works at, in one shot he raises his Grasshopper drink to his lips with his left hand. In the next shot it's in his right (this is just before he says "Oh my God, you've lost so much weight").
The Grasshopper Experiment - S1-E8
Continuity mistake: When Raj starts talking to Penny after he drinks the Grasshopper drink in her apartment, in one frontal shot he lifts the drink and begins to drink but in the next shot from behind the drink is back on the counter.
The Cooper-Hofstadter Polarization - S1-E9
Revealing mistake: When Leonard and Sheldon are fighting near the end they bump into the wall, which visibly shakes. (00:15:40)
The Cooper-Hofstadter Polarization - S1-E9
Continuity mistake: The video of the fight we see on Youtube is different to what we saw earlier in the episode.
Continuity mistake: When Sheldon is talking with Leonard in the kitchen at night, as he pours himself a mug of milk the mug moves between shots. (00:04:50)
Other mistake: Leonard says that it's 2am when his door is knocked on, but when he opens his door to confront Sheldon, his window outside shows daytime light. (04:12:00 - 04:25:00)
Character mistake: Sheldon is a well-documented and self-proclaimed germophobe. It is completely out of character for him to retrieve the bag of chicken from the trash.
Continuity mistake: Sheldon puts the bag in the bin at the start of the episode so that the handles are facing the ground. When he gets the bag out, the handles are at the top of the bin.
Audio problem: When Sheldon is knocking on Leonard's door at the start, the sound is out of sync with the action.
Continuity mistake: When Penny is telling Howard and Raj about Sheldon's "drug addicted cousin" her scarf keeps jumping in and out of her jacket.
Continuity mistake: In nearly every episode, Sheldon demonstrates his OCD when he knocks three times on a door, says a person's name, and repeats that sequence twice, for a total of three iterations, but in this episode he radically departs from that behavior not once but twice. First, wanting to talk to Leonard, he knocks four times, says "Leonard" and repeats the sequence three times for a total of four iterations. Later, wanting to talk to Penny, he knocks four times and says her name, repeating that sequence at least four more times. Given that this was the first season, I assume the writers had not yet settled upon the 3x3 routine as a comic behavior.
Continuity mistake: During the whole opening scene, the way in which Leonard holds the letters in his hands keeps differing.
Continuity mistake: Sheldon puts the bag of takeout into the lobby trash can and as he does so, the whole bag turns sideways. At the end of the scene, he takes the bag out of the can and it's upright without him turning it.
The Pancake Batter Anomaly - S1-E11
Continuity mistake: After Leonard gives Penny her pile of mail, she alternates from holding the pile by her side to at her front between each shot. (00:01:10)
The Pancake Batter Anomaly - S1-E11
Continuity mistake: When Sheldon walks out his bedroom wrapped in a comforter, he drops it on the higher level before the drop down to the kitchen. In the next shot as he walks away from the fridge, half of the comforter is now spread over the lower level without anyone moving it. (00:05:10)
The Pancake Batter Anomaly - S1-E11
Continuity mistake: The way Penny holds her notepad when talking to Sheldon at the Cheesecake factory keeps changing instantly. (00:10:10)
The Pancake Batter Anomaly - S1-E11
Factual error: Leonard's myopia is greatly exaggerated in this episode. Even with high myopia he should still be able to navigate his apartment without aid especially after living there for seven years. (00:17:40)