The Big Bran Hypothesis - S1-E2
Continuity mistake: At the end of the episode, when the gang is reading the furniture assembly instructions, a pencil in the cup in front of them suddenly vanishes. (00:19:00)
The Big Bran Hypothesis - S1-E2
Continuity mistake: When Sheldon is cleaning, he moves an iPod dock and the iPod lights up. Camera changes and the iPod is unlit. A few shots later it's lit again. (00:09:00)
The Big Bran Hypothesis - S1-E2
Continuity mistake: At the very end of the episode we see Penny with her hands on the corner of the piece of wood. Camera cut and now they are in the middle. (00:19:50)
The Big Bran Hypothesis - S1-E2
Continuity mistake: When Sheldon says the line about having no peers when cleaning the apartment, there is a pair of jeans on the side which disappears when the camera cuts. (00:10:00)
The Big Bran Hypothesis - S1-E2
Continuity mistake: When cleaning Penny's apartment, Sheldon is holding up a jacket. Camera cuts and he is no longer holding the jacket up. (00:09:50)
The Big Bran Hypothesis - S1-E2
Continuity mistake: When Leonard and Sheldon are pushing the box up the stairs, the position of the box on the stairs changes instantly. In one shot it is flush against the wall, then in the centre of the stairs. (00:05:20)
The Big Bran Hypothesis - S1-E2
Continuity mistake: When shifting the box along the floor of the 3rd floor landing, Leonard's grips on the box is constantly changing. (00:06:00)
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.