Continuity mistake: When the bottle of bourbon is found and taken out of Marge's pocket, the bottle is grey. But when Sanjay throws it to Apu, and Apu catches it, the bottle has now changed to a brown colour. (00:08:30)
Continuity mistake: When Marge comes to pay for her shopping, she empties her left pocket on her coat, but when Sanjay finds it in her pocket, it's in her left pocket. We know it wasn't in her pocket anyway because when Sanjay finds it, it is bigger than the size of her pocket.
Krusty Gets Kancelled - S4-E22
Continuity mistake: When Bart and Lisa are helping Bette Midler pick up trash on the highway, Bette picks up an empty can which says Buzz Cola on it. Just as she yells, "You pigs!" the label on the can switches to Duff Beer.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: When you see a shot of the church from outside in the scene where the bee sharps sing there, look closely at the sign. It says 'Also: The Bee Sharps', only they don't name themselves that until later on in that episode.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: In the flashback where Marge is making a model of Homer, the models head falls off and Santa's Little Helper picks it up, but the Simpsons did not own the dog back then.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: At the sale, when Bart and Lisa first find 'The Bee Sharps' album, the order of the records in the stack change in subsequent shots.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: At the end of the episode, while the B-sharps are singing on top of Moe's Cavern, the guy climbing the building asks the people to look at him. As he moves his hands, his gloves change color from red to white and back to red.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: When Homer is talking to George Harrison, he sees that he has a brownie. Then he rushes over to a pile of brownies and starts scoffing them down. The pile of brownies doesn't get smaller.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: In the deleted scene where the Be Sharps unveil 'Donut Records', Barney's hair flashes red a couple of times in the close-up of the band.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: Homer and Marge's bedroom has photos of Bart and Lisa when they were 10 and 8 years old. However, the story takes place when Bart and Lisa were only 3 and 1.
Homer's Barbershop Quartet - S5-E1
Continuity mistake: When Bart and Lisa find the record Melvin and the Squirrels, they hand it to the Comic Book Guy to play. While the record is in his hand you can still see it displayed on the rack.
Cape Feare - S5-E2
Continuity mistake: At the beginning of the episode when we see MacBain on TV he goes through a curtain, the curtain stays open for a second even though he isn't touching it.
Cape Feare - S5-E2
Continuity mistake: When Bob has finished singing the score of the H.M.S. Pinafore, an English flag comes down. But when he draws his sword to kill Bart, the flag is gone. Where could it have gone?
Cape Feare - S5-E2
Continuity mistake: When Bob is working out on the weights, he has a tattoo of something on his knuckles, but when he is watching the exercise video, the tattoo dissappears.
Continuity mistake: Just after Homer has used the proton accelerator, Dean talks to him. In this scene he is writing something on a piece of paper, but he writes on the same line every time. He finishes writing on that line, then starts on it again.
Continuity mistake: The colour of the alien poster in the nerds' room changes from pink to blue.
Tree House of Horror IV: The Simpson's Halloween Special IV - S5-E5
Continuity mistake: In "Terror at 5 1/2 Feet", when Milhouse decides that he is going to sit next to Uter, Uter all of sudden moves to the other side of the seat between shots.
Tree House of Horror IV: The Simpson's Halloween Special IV - S5-E5
Continuity mistake: At the end just before the Simpsons say "Happy Halloween everybody" they are about to bite Lisa (and make her a vampire). Maggie has no dummy (or in America, pacifier) in her mouth, but it suddenly appears when she closes her mouth.
Tree House of Horror IV: The Simpson's Halloween Special IV - S5-E5
Continuity mistake: When Otto hits Hans Moleman's car, it has a number plate on it, which disappears when he crashes.
Tree House of Horror IV: The Simpson's Halloween Special IV - S5-E5
Continuity mistake: Just before Homer is sucked into Hell, he is wearing pyjamas. When he's in Hell, he's wearing his usual day clothes.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer