Audio problem: When Riker leaves Deanna and Wyatt at the holodeck you hear the door. You don't hear it a minute ago, when Wyatt enters the holodeck - he just appears. (00:27:30 - 00:28:15)
When The Bough Breaks - S1-E17
Audio problem: Riker's lips don't match what he is saying when we hear Riker's statement of being surprised when Tasha hasn't heard of the stories of Aldea.
Audio problem: Near the end, when Leech points his gun at Crusher, there is the sound of him cocking the weapon. However, when we see his gun immediately thereafter, the hammer is in the uncocked position.
Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73