Revealing mistake: Grace is lugging two suitcases down the stairs. She is acting as if they are very heavy. Ben offers to help and takes them from her. But he carries one with a bent elbow, and it is obvious that it is not really heavy at all. (00:13:30)
Other mistake: Micaela and her partner are chasing an RV. A man from the RV throws a propane tank in her path. You can tell from the sound and how it bounces that it is empty. When the car hits it, the tank explodes, and she swerves the car into the brush and the airbags deploy. Later, as she is driving on the same road she gets a call that the RV has been spotted. Her car shows no damage. (00:17:44 - 00:29:10)
Factual error: Micaela was pushed off a cliff and landed on a ledge, and tells Zeke she has dislocated her shoulder. Zeke helps her get back to the top, and for the last push, she puts out both arms and Zeke pulls her to safety. Not possible. A person with a dislocated shoulder would not be able to move that arm.
Continuity mistake: In season 1, the pilot episode, the tail fin of the plane is blue with a white logo only. Starting season 3, the tail fin has "Montego Airways" written in red above the white logo. In most episodes, the tail fin is shown from the other side than the one shown in the pilot episode but in the last episode, when the tail fin falls in the water, you can see both sides with the red writing above the logo. (00:30:57 - 00:41:27)
Other mistake: After Michaela and Astrid saved Coby Webber's son, you can see a NYPD car which is assigned to the 29th precinct. First of all there is no 29th precinct, and if there was a 29th precinct, it would be located in Manhattan, since all precincts in Manhattan are numbered in the 1 to 34 range. Also, it is shown that the house is on the countryside, so it is out of the NYPD jurisdiction.
Other mistake: They assemble nine of Cal's drawings into one. But the final arrangement has a white outer border. Clearly a poster that was cut into nine pieces, not nine drawings.
Factual error: Escorting Saanvi and her colleague to see Dr. Cooper, NSA Agent Tim Powell flashes a gold badge and shouts "NSA" to the officers. NSA agents carry ID Badges, but not gold shields. Further, they would never identify themselves as NSA personnel to outsiders.
Answer: Only superficially. Manifest doesn't even begin with a plane crash, but rather a plane disappearing for 5 years with the assumption that it crashed, which turns out not to be true.
BaconIsMyBFF
In the particulars it seems different, but the overall plot is the same. A seemingly random group on an airplane experience a weird event and spend years trying to figure out what happened. Let's hope the reveal in the final episode is not as disappointing as "LOST" - they're actually all dead.