Continuity mistake: Michaela was shot on her right side, but when she meets Zeke on the street, she is holding her left side.
Factual error: When Saanvi reads the "paternity confirmed" test results, the child's alleles do not include the obligate/matching allele. (00:27:30)
Factual error: In a flashback scene, Dr. Saanvi Bahl is sending a voicemail to her partner on an IPhone 5S, just before Flight 828 takes off. The IPhone 5S was released in September of 2013, and Flight 828 disappeared in April of 2013 in the series. (00:01:08)
Continuity mistake: In the hospital ben sits next to his wife's bed. Ben has no glasses on. In one cut he has the glasses on and the next they are gone again, then a few seconds later you see him put on the glasses. (00:19:00)
Return Trip - S2-E6
Factual error: Liver dysfunction is detected when Saanvi sees Theo has bright yellow irises. Jaundice turns the whites of the eyes a dull yellow, not the iris. (00:15:09)
Factual error: Ben asks Yale University library to loan him a medieval diary and they immediately send it to him. No library or archive in the world would loan out a unique item like this, even to another university. Usually they are not allowed to leave the premises, except under very strict conditions for a high-profile exhibition, certainly not just sent to an academic who's interested in reading them.
Factual error: The thief Michaela chases down, would actually have a very hard time getting his hands on the cold medicine supposedly used to cook meth. A law was passed in 2006 that requires all retail stores to keep these products behind the counter and in a locked case because they contain pseudoephedrine, which is used in the manufacturing of illegal drugs, i.e. meth. This episode is set in 2019, yet the thief is able to swipe the medicine from the floor display. Not possible. (00:06:20)
Continuity mistake: When Zeke is sitting in the hospital, next to medical equipment, it disappears from the scene when he stands up and walks away. (00:23:53)
Answer: Only superficially. Manifest doesn't even begin with a plane crash, but rather a plane disappearing for 5 years with the assumption that it crashed, which turns out not to be true.
BaconIsMyBFF
In the particulars it seems different, but the overall plot is the same. A seemingly random group on an airplane experience a weird event and spend years trying to figure out what happened. Let's hope the reveal in the final episode is not as disappointing as "LOST" - they're actually all dead.