Continuity mistake: In the scene where Sam, Carly and others slide down the collapsing building, the shot from above reveals only one window hole where they could have jumped from, and Sam and Carly are sliding quite far off to the side from the hole.
Continuity mistake: In the highway chase scene, one of the Decepticons knocks down the freeway sign which causes the signs, originally facing the on coming cars, to flip away from them. The other two Decpticons then use the signs to as a ramp to get further down the road. This should be impossible because the signs didn't land that way. When the Decepticons land, the signs are pointing the first way again.
Continuity mistake: Towards the end of the movie, when Dylan is pointing a gun at Sam, he has both hands on the gun. In shots of Sam, one of his hands is on his side.
Continuity mistake: Towards the end of the film Carly is holding Sam, in some shots she has dirty hands in front of his shoulders and in other shots she has clean hands that are over his shoulder.
Continuity mistake: When the Autobots return from their fake deaths, Optimus shoots down an enemy ship by destroying the right turbine, making it crash down and saving Sam. But later on, Bumblebee starts it up and flies it with no apparent damage.
Continuity mistake: Just before Optimus Prime arrives in the street where he kills ten Decepticons in twenty seconds, there is a shot of Sentinel saying "It's our world now!", and he is looking out over that same street. When Sam comes out of cover to take a look at Cybertron, Sentinel is still on the building. But when Sam shouts "Optimus!" Sentinel is gone.
Continuity mistake: In the scene when the characters are sliding down the glass building, just before they shoot the windows, there is a shot where a chair is sliding down along them on the left side. The camera dips down for a moment, and when it goes back up, the chair is gone, even though there is no hole in the building for it to go.
Continuity mistake: When Charlotte Mearing, the United States Director of National Intelligence is talking to Optimus Prime about the teleportation device, the position of her hands on the red hand rail differs between shots.
Continuity mistake: After Ironhide crashes into the two remaining Dreads, both of them transform. We get a close-up of one of them, who transforms over a lamppost, about 10 feet above it. The next shot has him past the lamppost, and at the same height as the lantern itself - instantly.
Continuity mistake: When Optimus takes the roll to avoid getting shot by Shockwave, you can see the very distinct clock of the Hotchkiss building can be seen in the background, yet they aren't fighting in front of that. In the next shots, the building in front of which Optimus rips out Shockwave's eye is much more modern.
Continuity mistake: During the freeway chase, there is a shot with Hatchet landing on a car on the opposite side of the freeway. This shot has all sorts of poles on the center guardrail, and structures in the background. Then the poles in the center disappear, and the white-ish buildings in the background change into a bridge.
Continuity mistake: When Optimus takes a dive after his rampage in front of Shockwave, you can see that it is actually in front of the building with the control pillar in it (note the very distinct clock in the background) yet when Optimus shoots the dome and the pillar down, he's a good distance away from it.
Continuity mistake: When NEST is tracking The Dreads, in the satellite shot there is hardly any traffic on the freeway. However, in the shot immediately afterwards, it's very busy.
Continuity mistake: When the Autobots return to base to protect Sentinel Prime, when they enter you see Sideswipe after Sentinel Prime, but when they are in you see Ironhide after Sentinel Prime instead.
Continuity mistake: When Carly nearly reaches Megatron, there is a slow-motion shot of her with an SUV blowing up in the background. In the first shot, it flies up in an upright position. In the second shot, it suddenly spinning.
Continuity mistake: When The Ark escapes Cybertron it is hit by a missile tearing off a massive chunk out of one of its wings. Yet when it crashes on the moon, both wings are fully intact.
Continuity mistake: During the final fight between Optimus and Sentinel, a long curved copper pipe going from Sentinel Prime's chest to his right arm disappears and reappears between shots. And it isn't torn of in the fight between only the Prime's, I cannot say if Megatron doesn't remove it later on.
Continuity mistake: During the freeway chase scene, Bumblebee widens his tires considerably for better braking abilities. In the next shot, the rest of him/the car is instantly semi-transformed.
Continuity mistake: When Carly shows Sam the stuffed bunny, her hair is curly. Then when she jumps on the bed, her hair is straight.
Continuity mistake: Sideswipe's rims keep changing throughout the movie. At some point he has rims which have a pretty big distance between the edge and the actual spokes and at other points he has rims which have the spokes on the edge of the wheels all together.