Partners in Danger Chapter 10: Lizard King - S4-E10
Plot hole: When Debra and Margaret arrive at the underground arena with the device that can revert the humanoid lizards to their original forms, they lose control of the device and it ends up in the hands of Ghila, who monologues that the humanoid lizards' existence was an accident and that she will use the device to return them to being regular lizards. Ghila had never seen this device before, nor did anyone tell her what its purpose was, so there's no way she could have known it was designed to reverse the mutations.
Answer: Yes. Many things that would have been in the sixth season would have had Norman Osborne returning from limbo and reclaiming the title of the Green Goblin, Richard Fisk, the son of "The Kingpin" Wilson Fisk would return as a crime lord known as "The Rose", Ghost Rider would have appeared to help Spider-Man stop Dormammu from returning to Earth and Madame Web and Spider-Man would rescue Mary Jane from limbo.