The Big Bang Theory (2007)
0 plot holes in season 1 - chronological order
Starring: Kaley Cuoco, Johnny Galecki, Melissa Rauch, Simon Helberg, Jim Parsons, Kunal Nayyar
Genres: Comedy
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The Countdown Reflection - S5-E24
Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
The Extract Obliteration - S6-E6
Stephen Hawking: Do you like brain teasers?
Sheldon Cooper: Oh, I love brain teasers.
Stephen Hawking: What do Sheldon Cooper and a black hole have in common? They both suck. Neener, neener.
The Work Song Nanocluster - S2-E18
Trivia: After Sheldon mentions a molecular sieve, they go over to 4a, their apartment. 4a is a kind of molecular sieve.
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Answer: Because Raj's selective mutism seems to be caused by women that Raj sees (on some sort of conscious or subconscious level) as a potential sexual partner. An attribute that wouldn't apply to either his sister or mother.