Visible crew/equipment: You can see the boom mic above Picards head when he is in his quarters. (00:11:30)
Revealing mistake: When Picard and Cmdr. Daron are in Picard's quarters together for the first time, watch Picard play his Inner Light theme. The hands playing the flute are obviously not his.
Commander William T. Riker: In your position it's important to ask yourself one question: what would Picard do?
Wesley Crusher: He'd listen to everyone's opinion and then make his own decision.
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Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73