All Along the Watchtower: Part 2 - S3-E6
Continuity mistake: The team and the hostages escape from the compound in an SUV and a school bus with the SUV in the lead. They are being pursued by a small truck with a mounted machine gun which starts firing on the school bus. They switch positions, moving the SUV behind the bus so that they can protect the hostages and return fire. The next shot in the command post via a drone shows the original lineup, with the school bus behind the SUV.
Answer: Yes. They would have to land 3-4 times for refuelling. The plane could fly with the wheels down, but the additional drag slows the plane and increases fuel consumption.