Continuity mistake: Bartman Begins: When Bart shows the Squeaky Voiced Teen the Cal's Calzone Frequent Calzone Eaters card, he first has three fingers placed on the card - one above the other finger with the side of his finger placed on the card and the same for the second one below it and a third finger pushed against the second. In a sudden close-up of the card, it is now four fingers pushed against the back of the card.
Continuity mistake: Game Over: When the Simpsons meet God, the Simpsons go from looking at God to looking 90° in the opposite direction between shots.
Continuity mistake: Game Over: On the Wii and PSP versions, just as the opening cutscene finishes, Shakespeare is standing atop the gates to heaven, but as soon as the level starts, Shakespeare is standing on the ground.
Continuity mistake: Five Characters In Search Of An Author: Maggie suddenly appears on Marge's baby carrier as soon as the game engine start to crumble. She nor the baby carrier attached to Marge was never visible at any point before this.
Continuity mistake: Five Characters In Search Of An Author: When Matt Groening unveils the Game Engine self destruct button, the painting hiding it changes position in relation to the self destruct button between shots.
Continuity mistake: Five Characters In Search Of An Author: After you have reached the interior of the mansion, try and run up a staircase as Bart. If you change the camera angle to an aerial shot and walk up the staircase, a chandelier will appear. If you do nothing the chandelier will just vanish from shot, despite not having moved.
Continuity mistake: Grand Theft Scratchy: The woman in blue gets crushed by the huge heart fixed onto the sweet store. This heart was never visible during the wide shot at the start of the cut scene.
Continuity mistake: Bargain Bin: When Homer places the Duff can on the computer DVD player, the can falls over and spills on the keyboard. In the next shot, the Duff can vanishes.
Continuity mistake: Enter The Cheatrix: After Bart and Lisa break into Frink's basement, they discover a Rift Portal. The first shot shows the "DO NOT USE" sign a foot above Bart and Lisa's height. But as Bart walks into the portal, the sign is suddenly located at the same height as Bart.
Continuity mistake: Around The World In 80 Bites: In the ending cutscene, the losing contestants have to clean up. There's hardly any mess when they start cleaning. But the place is suddenly filled with mess when Comic Book Guy says "Less references, more mopping" to Willie.
Continuity mistake: Bartman Begins: After Bart flies onto the seal forming the bridge, a cutscene is then shown of Homer and Bart standing next to a glass wall witnessing the bullies stealing the artifacts. When it returns to the game, Homer and Bart are back on the seal.
Continuity mistake: Big Super Happy Fun Fun Game: When Milhouse is about to give the key card to Homer and Lisa, he extends his arm to hand it to them and puts his arm in a bent position. In the next shot, his arm is fully extended, with no visible bend.
Continuity mistake: Lisa The Tree Hugger: Lisa takes the The Simpsons Game manual off Bart. After Bart says "Can we skip this level?", Lisa starts talking to Bart and the manual has disappeared. There was also nowhere for Lisa to put the manual.
Continuity mistake: Level 2 "Bartman Begins" cutscene: When the game instruction manual appears in front of Bart, with Homer on the front cover and a blue back cover, the manual's spine is at the left and it opens at the right, but when Bartman explains to Homer that he's now a superhero with awesome powers, the manual's spine is now at the right and it opens at the left.
Continuity mistake: Level 2 "Bartman Begins" cutscene: After Marge confiscates Bart's video game, when Bart complains about "nothing to play" we see the corner of the museum across the street and there are no crosswalk lines, nor is there a fire hydrant, but when Bart starts reading the game instruction manual there's a red fire hydrant at the corner as well as white crosswalk lines, then when Homer appears they vanish again.
Continuity mistake: Level 2 "Bartman Begins" cutscene: After Skinner's confession, when Wiggum arrives at the museum with Eddie and Lou, note Wiggum's red tie clip changes to grey then back to red, at least three times.
Continuity mistake: Level 4 "Lisa the Tree Hugger" cutscene: When Bart and Lisa are at the front gate of Auntie Nature, note the direction of the blade points on the doors are going clockwise, but in a few closeups the blade points are going anti-clockwise.
Continuity mistake: Level 4 "Lisa the Tree Hugger" cutscene: When Mr. Burns tells Smithers about his plan to cut down Springfield's forests, in the first overhead shot we see books and a telephone directly beside the desk pad, but when Smithers tells Burns it's a great idea that area of the desk is empty.
Continuity mistake: Level 5 "Mob Rules" cutscene: When Lisa shouts that they're being invaded Marge is wearing the baby carrier with Maggie, but in the exterior shot of the entire house Marge is not wearing the baby carrier, note the two shoulder straps and waist strap are gone, then Marge is babywearing again in following shots. Also note that when Bart tells them about their "super responsibilities" the doorbell has vanished.
Continuity mistake: Level 5 "Mob Rules" cutscene: There's an exterior shot of the Simpson house and their neighbor's house right before Homer tells his family that it was greatest day of his life. After Bart tells his family they should "go kick some alien butts," there's another shot of the houses, and the Simpson house is missing its antenna, mailbox, etc., and the style of the neighbor's house has changed, note its windows and roof.
