Audio problem: As Alice, Claire, Chris, Luther and Kim are on the rooftop shooting the zombies as they rush towards them, you can see Chris' lips move as if he is shouting something to the others but no words can be heard coming out. (00:59:10)
Other mistake: At the end of the fight with the Axeman, Alice points a shotgun towards him, while both she and Claire are sitting on their knees (as is seen in the overhead shot with the axe in the wall). But the shotgun is clearly pointed downwards. Alice is 5'9'', while the Axeman is at least 9 ft. tall. If she wants to blow his head off, she should have been pointing it more up. (01:07:40)
Continuity mistake: After the Needle dive, Alice lands on a table. When she is shot by Wesker, the table is covered in blood. In the overhead shot afterwards, the amount of blood changes drastically. (00:12:05)
Continuity mistake: After Wesker flees Arcadia in the Umbrella chopper, though he himself has the ability to heal extremely quickly, his clothes no longer have bullet holes in them.
Factual error: Just after Alice jumps from the tower and draws her dual revolvers, the film slows down to bullet time to show her shooting two zombies. If the speed of the bullet is accurate, there's no way she can move so fast as to then run and get out her shotguns. (01:03:40)
Continuity mistake: Alice drops her shotguns after she is knocked out by the Axeman, and a close up of the shotgun shows that it lands near one of the shower columns. And when Claire spots the shotgun, it is still lying in the spot where Alice dropped it. But in the wide shot just before Claire starts her slide, the one with both Claire and the Axeman, there aren't any more of the shower columns between them, and Claire only picks up the shotgun after the wide shot. (01:03:55)
Visible crew/equipment: When Chris is released, he stands in the doorway and says "I wondered how long it would take." When he does a boom arm can be seen moving in the glass to screen left. (00:49:20)
Continuity mistake: In the shower scene the shower is turned off but you can still hear it running. Then it switches back on. You can see it off and on during same scene but the sound is always running. (00:50:00)
Suggested correction: There are numerous times that the shower is running. When you can hear water but not see it, you're looking at a different shower pole, or it's because the grey shower pole behind the stream makes it hard to see. Look at the ground and you can see the water's impact.
Continuity mistake: In the flashback when Claire remembers what really happened on the beach where they landed the chopper, the Umbrella guard slams the spider-shaped device on her chest. In the next two shots, the device is gone, but when Alice finds her 18 months later, it's back on. (01:10:50)
Continuity mistake: Luther shoots the Axeman in the head, just above where his left eye should be. When the Axeman reaches the shower, the hole in the burlap sack and the blood are gone. (00:54:40 - 01:05:00)
Continuity mistake: Bennett stabs Alice in her lower arm, from the top to bottom, probably between the bones. But in the revolving shot which reveals Wesker, the knife is suddenly facing side to side, meaning the knife would be going over the bones.
Continuity mistake: When Alice is about to blow up the elevator, we get a shot of a big explosion. Anderson has been nice enough to slow this down for us, so you can see that the elevator is empty, where before there were four people. (00:59:30)
Continuity mistake: When Bennett shoots Angel, the blood covers Kim's right shoulder. We then get a shot of Bennett, and when the camera cuts back to Kim, some of the blood has already dried up, in less then a second. (00:56:40)
Revealing mistake: After Bennett takes off, Luther jumps on the edge of the prison. When he hits it, you can see the seemingly solid concrete edge wobble.
Revealing mistake: Just before the group enters the elevator which Alice blows up, they are all shooting at the horde of zombies. But pay close attention to Alice's MP5K. There are no empty shells flying away from it, which means the gun ran out of blanks and the flares were edited in later on. Also, we can see the empty cases flying away from Luthers gun, who is even further away from the camera. (00:58:50)
Continuity mistake: Just when Alice jumps off the roof, pay close attention to the zombie directly to her right. You can see how he slows down and stops on the ledge. But in the shot directly afterwards, all of the zombies are jumping after Alice, and none are stopping where the roof ends. (01:00:10)
Continuity mistake: After the Tower Swing, Alice fires a bunch of quarters through two zombies, most of which end up in the wall around Luther. But when he has closed the door, we get an overhead shot of the wall, which has a bullet hole in it - and no quarters. (01:04:15)
Factual error: Alice blows up the wires of the elevator to bring it down as quickly as possible. But all elevators have emergency brakes to prevent precisely that from happening. The chances of them being damaged by rust are also very slim: they are covered in grease. (00:59:35)
Factual error: The blood stream on Wesker's head is wrong. He is leaning over to his right, and the blood coming straight out of the wound is going slightly to the right, and then straight down, so far so good. But at the angle he is lying, the blood should have stopped at his eye, and even if it did jump over his eye socket, it should have been directly below or even more to the right of where the first stream ends.
Continuity mistake: In the scene after Alice bungee's off the roof, as she runs through the crowd of zombies towards Luthor, she fires the shotgun loaded with quarters once. As she gets closer he jumps to pull the door down and as all the zombies hit the door, you can see that it's solid, no holes. But when the shot changes to the inside view, the door now has quite a few holes in it. Not only were they not there before, but the door was open, so the quarters wouldn't have hit it anyway. (01:03:50 - 01:04:20)