Continuity mistake: When the zombie dog jumps through the window Alice makes a run through the metal door and you can see the door is clean. When it cuts there is lots of blood on the door even before the zombie dog jumps on it. (00:47:45)
Visible crew/equipment: When the team leader asks Alice for her report, if you look in the reflection of the eye pieces on his mask, next to Alice's head, you can see a man wearing jeans. This happens twice. (00:13:23)
Plot hole: When the umbrella ops first get onto the train, rain has to power it up. There were plugs disconnected, and you see a hole in the fence as she shines a flashlight on it. It can't be anything infected because they didn't power down the red queen yet, and release the bioweapons. The red queen isn't physical, just controls systems. And with none of the zombies, or other infected loose yet, what else could have unplugged it? Spence was knocked out on the train, this seems to be a plot hole. (00:02:00 - 00:20:10)
Continuity mistake: At the start of the film, the scientists are attempting to breach the window with an axe. Later in the same lab in the movie, Alice picks up an axe, even though it was shown before being wielded by the zombie.
Continuity mistake: Alice wakes up at the end and is completely nude with the exception of some paper taped to her front. We see when crawls under the bed that this is the case. However as she is cocking the shotgun in the streets the wind blows open to the doctor's jacket she put on earlier, but it also shows that she is now wearing white underwear to hide her modesty in case of a mishap with the wind. (01:30:00)
Continuity mistake: When the Lasers have finished killing everyone, the EMP equipment is next to the glass wall. When Alice walks over and looks in to the corridor, it's moved. (00:32:20)
Continuity mistake: In the beginning when the the cylinders are being placed in the holders, in one close-up you can see the middle cylinder being placed and that there is no cylinder to the right of it. When it cuts a cylinder has suddenly appeared. (00:02:20)
Revealing mistake: In the scene where Milla Jovovich shoots the dogs with the 9mm Beretta she obtained from the dead security guard, a closeup of the gun is shown. Watch the cycling of the slide and you will notice that the ends of the bullets are crimped, indicating the use of blanks. (00:49:55)
Continuity mistake: Shortly after the Licker pulls Kaplan out of the train, Matt shuts the door so it can't get at the rest of them. The Licker goes on the roof to use the back entrance to get into the car. Matt hears this and rushes to bar the back door. Pay attention to the near dead Raine. She suddenly gets a lot more life and quickly moves out of the way to avoid being accidently trampled. (01:24:55)
Deliberate mistake: When the woman is attempting to escape from the elevator, it dislodges and falls down, so then the actress is facing the ground...but when her arm hits the floor, the floor itself bends. If you watch the DVD with the commentary on, the director points out that it was a break away floor in case the actress' head accidentally snapped forward, to avoid any injury. (00:08:00)
Continuity mistake: When the person is bumped into and spills coffee on himself, the coffee stains on his shirt changes between the shots. (00:03:05)
Continuity mistake: When Matt is at Lisa's desk he looks through some papers, he is looking at a paper which has black squares on it. Then he puts the paper down and looks at another paper. When it cuts to him noticing Lisa approaching he is now holding the paper with the black squares again. (00:50:20)
Audio problem: When Matt is trying to reach the keys while kicking the zombie it cuts to Chad running against Spence who's standing by the locked door. When Chad is running you can see Rain in the background firing shots but you can't hear the shots. (00:42:15)
Continuity mistake: When Alice wakes up in the shower, in one shot, you can see the shower curtain is not hanging over the edge of the shower. But when it cuts, it is. (00:08:40)
Continuity mistake: When they are entering the entrance to the Queen's chamber, the Medic is carrying a bag as you can see when the door closes. When it cuts from inside the entrance the bag has disappeared. (00:30:50)
Continuity mistake: When Kaplan tells Alice not to listen to the Queen he is carrying the equipment by his right shoulder. When it cuts it has suddenly moved over to his left shoulder. (00:34:45)
Factual error: When Alice has the pistol she got from the zombie she took out, she uses it to do away with the zombie dogs. As she fires the last of the rounds, the camera looks down to follow the fall of the casing. As it falls, it's on a slight tilt, about 5°. Physics says that it will bounce and tumble on the floor after it hits, then come to rest. Instead, when it hits, it immediately goes to a rest position with little movement. (00:48:20)
Continuity mistake: On the train, just after Spence falls in, Alice takes off her wedding ring and sees on the inside: Property of Umbrella Corporation. However, after she finishes off Spence, she drops the ring next to him, and in that shot, the inside is clean; or at least the half we can see when it lies still. Such a long line would take up a lot of room on such a small ring in that size text. (00:17:45 - 01:19:05)
Revealing mistake: When Alice hits the zombie Spence in the head, she misses Spence by a lot. (01:18:50)
Revealing mistake: When Alice hits the first person in a biohazard suit, the padding is visible on the chest section. (01:25:40)
Answer: Actually the T-Virus was originally meant as a cure for a genetic disorder that Dr. Ashford and James Marcus daughters suffered from. The reanimation was a side effect and James Marcus was killed by Dr. Alexander Isaacs so he could take control of it and turn it into a bio-weapon.
lionhead