Continuity mistake: Near the end of the film, on the train ride out of the Hive, Rain is quite close to becoming undead. When she speaks, we notice her teeth are still "movie-star white". However, a few shots later, when she becomes a zombie, she sort of hisses where you can see it has taken what couldn't have been more than a few mere minutes for her teeth to become brown and discolored. (01:21:00)
Continuity mistake: Near the beginning of the movie, Milla Jovovich reads a note that has been left on the desk. She didn't write it, as they demonstrate in the film. However, when they do show the person who wrote the note composing it, the handwriting is different from that in the note from the earlier scene. (00:10:20 - 01:12:25)
Continuity mistake: When Matt gets scratched by the mutated Licker at the end of the film, the scratches on his arm appear before the creature's claws actually hit him. (01:24:15)
Factual error: When the special forces arrive in the Station of the hive, the computer identifies the soldier`s weapons. The name under the picture is right, but the picture always shows an MP5, even at the soldier carrying a G36 Assault rifle. (00:19:20)
Factual error: Medic gets killed by the laser which cuts her head off, In doing this, her spinal cord is severed meaning her muscles would not be controlled. Yet she still manages to stay standing. (00:31:20)
Revealing mistake: When the group is being attacked in dining hall B, they are trying to get the doors open. J.D. is firing at two zombies and turns away to open the doors himself because Kaplan keeps forgetting the code. If you look closely, one of the zombies reacts a second late from being shot down. (00:44:40)
Factual error: The case containing the virus requires a four digit code to open it. As demonstrated by the operative that opened it to give himself the antidote near the train. Yet Alice closes the case, and later opens it without entering a code.
Other mistake: When we see the numbers for the coded entry to Alice's weapon, the order of the numbers is 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 0 - 9. The 9 and 0 are the wrong way round. (00:47:40)
Other mistake: When the train arrives back under the mansion from the Hive, it enters the station from the wrong direction. Looking at the track from the platform, the train comes in from right to left, when it should be from left to right. (01:27:20)
Revealing mistake: When the team leader is opening the door to the Red Queen chamber, he clips an electronic device to the door to hack the code. The device is actually a blood glucose monitor as used by diabetics - an Accu-Chek, I think. (00:31:05)
Other mistake: Watch Milla Jojovich's hair during the scene when they are held at gunpoint by Spence. Her hair moves from shot to shot. For the most obvious, watch right after Spence shoots the zombie. (01:15:25)
Revealing mistake: On the DVD commentary, the director says that he only had a handful of the experiment cubes in Dining Hall B and used cardboard cutouts for all the others. This is most obvious when Rain is walking through the hall alone to check on the first zombie: the cubes in the distance don't match the rigid rows of the ones in the foreground. (00:38:20)
Visible crew/equipment: When JD shoots the zombie female in her leg you can see the square outline of the pack behind her leg that 'explodes' and makes the hole in her pants. (00:38:10)
Audio problem: When Spence is killed by the Licker, Matt sees this on the screen and asks, "What the f**k was that?" You can see that his jaw isn't moving. (01:17:25)
Continuity mistake: Near the end, when Alice, Rain and Matt are talking to the "Red Queen" in the virus lab, there is a wall-mounted LG Flatron TFT display where the Red Queen shows surveillance footage, etc. One can see an inventory type barcode label in the bottom centre of the screen. The camera cuts away briefly, and when the camera shows the display again, the barcode label is gone and the LG logo is in its place. (01:14:50)
Continuity mistake: When zombie Lisa lies dead on the floor her hair and the papers she lies on change position between the shots. (00:50:55)
Continuity mistake: When Alice escapes the first zombie dog and locks herself in the room, a zombie approaches her and she kicks him down. When the zombie falls you can see his tie is partially outside of his suit. When it cuts to Alice reaching for his gun, the tie is tucked inside his suit. (00:47:20)
Continuity mistake: The way the T-Virus capsule hits the ground is the same each time they show it, however when it's on the ground and motionless, the position is changes. During the flash back at the end that Spencer is having, the capsule is all over the place. However at the beginning, the capsule is just in a little straight pile on the floor. (00:03:15 - 01:09:30)
Revealing mistake: When the survivors first get into the sewers, the camera goes forward on the dolly as they come around the corner. Until the camera gets its close up of Alice, everyone's hugging the wall to get out of the camera's way. (01:01:00)
Other mistake: During the scene with the laser, the laser moves along the floor where the EMP device is located, several times. However, when Kaplan and Alice enter the room, the bag with the EMP unit is still intact. (00:31:15)
Answer: Actually the T-Virus was originally meant as a cure for a genetic disorder that Dr. Ashford and James Marcus daughters suffered from. The reanimation was a side effect and James Marcus was killed by Dr. Alexander Isaacs so he could take control of it and turn it into a bio-weapon.
lionhead