Revealing mistake: When Warren begins shooting Bob, a massive blood spurt is shown each time he shoots him. Each time he is shot, the blood spurts don't line up with the area where Warren shoots at. The first time Warren shoots Bob, the gun is showing firing at his stomach, but the blood is shown spurting from his chest and the second time he shoots Bob, the gun is fired at the top of his chest, but the blood spurts come from a couple of inches below where he was shot. (01:57:00)
The Hateful Eight (2015)
1 revealing mistake - chronological order
Directed by: Quentin Tarantino
Starring: Samuel L. Jackson, Kurt Russell, Tim Roth, Channing Tatum, Jennifer Jason Leigh
Genres: Western
Continuity mistake: When they pick up Warren on the stagecoach, the second shot from inside has the wrong direction of landscape outside, so it seems that Warren changed from the front to the back row.
John Ruth: No one said this job was supposed to be easy.
Major Marquis Warren: Nobody said it's supposed to be that hard, either.
Trivia: The guitar that Domergue plays and that was subsequently destroyed by Ruth was a priceless antique from the 1870's on loan from the Martin Guitar Museum. Six replicas were made for the film, however Kurt Russell was misinformed and destroyed the original. Due to this the Martin Guitar Museum said they would never lend an instrument to film shoots ever again. (01:38:00 - 01:42:30)
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Answer: It's not PURELY fictional, as plenty of poisons lead to vomiting and bleeding (cyanide, arsenic, etc.), but Tarantino, as is his wont, definitely takes some artistic license and kicks it up several notches for dramatic/gross-out effect.