Plot hole: In the scene where she goes to her house after escaping there is no police tape on the front door even though it is a crime scene. Earlier the police searched and taped her office - it only makes sense that they would do the same to her house.
Continuity mistake: When William Petersen is talking to his kid in the supermarket, the cereal boxes behind him on the shelves change between two shots. The items behind Kevin also change during the scene. (01:09:05 - 01:10:20)
Continuity mistake: When Wednesday and Pugsley are playing with the guillotine, Wednesday has a scroll in her hands, which she then rolls up. The shot changes and you can still see the rolled up scroll in her hands. However, the shot then changes again and you can now see Wednesday rolling up the already rolled up scroll.
Visible crew/equipment: When the woman is performing an autopsy on one of the dead "creatures" the lights supposedly flicker and turn off. There is a hand visible flicking the switches on the lamp to the right side of the screen. (00:45:40)
Plot hole: No one wonders what happened to all the staff and patients at that sanatorium? No police ever came there and checked the place out after 30 years? And all the patient records, furniture, etc are still there?
Continuity mistake: When the police car rolls out of the car wash, both passenger and driver's doors are open. When the shot changes to the deputy holding the rifle, the driver's door is closed. In the next shot both doors are open again.
Factual error: The actual Tsavo lions responsible for the killings had no manes - see for yourself; they are on display at the Field Museum in Chicago. [The filmmakers employed artistic license in using maned lions. They were also certain to include - at the very end of the movie - footage of the real Tsavo man eaters, as they appear in the Field Museum.]
Continuity mistake: When Frankie is about to receive the first stigmata (when sitting in the bath), a pigeon suddenly flies up. When she takes a piece of a feather that flew into the water, you can already see stigmata marks on her right-hand wrists.
Audio problem: Just after the car crash, when the zombies are taking Starla, Bill and Kylie yell after her, but they call her Carla.
Continuity mistake: In the scene where Eddie Murphy is going into the crypt, he takes one of the lit torches. While they are trying to escape the skeletons, the door to the crypt closes and locks. When they show the shot of his son outside, you see two torches again. When he gets the doors open and they leave, you see one.
Factual error: In keeping with the theme of the Ten Plagues of Egypt, Doctor Phibes has one of his victims eaten alive by locusts. Not likely. Locusts are strictly herbivorous, and like all herbivores locusts won't touch anything that moves. They would not be attracted by the slimy goo poured over their 'victim', because they zero in on plant pheromones and nothing else.
Continuity mistake: In the scene where Thora Birch's character goes to a café with her psychologist, the psychologist takes a bite of a cake and puts it back on the table. In the next scene, the cake has not been touched.
Other mistake: Towards the end of the film, after Snipes beats up of a lot of vampires, Whistler throws Blade's sunglasses to him. They show him throw them in one shot, then in the next shot they show Snipes catching them. But look in the background at Whistler, he doesn't have the glasses, but is moving his arm like he is throwing them. The glasses must have been computer animated, and bad editing contributed to this mistake. (01:37:34)
Revealing mistake: When Tiffany calls Ruth Bailey, you can see that the mobile phone she uses is turned off.
Visible crew/equipment: When Francesco and 'she' are in the cemetery together and the little blue flame-beings gather around to watch them, you can see the wires they're suspended on several times. This is most apparent when Francesco sees the first one (moments before seeing 'she' at the fountain) and also just before they are all frightened away. (00:17:30 - 00:20:40)
Plot hole: During the end the murderer is thrown out the front window of the building. The students leave the building through the front door, but yet there is no body, and that doesn't seem to bother them!
Audio problem: A soda can that is supposed to be full hits the man. When the can hits the ground you can hear that it's empty.
Visible crew/equipment: 25:05 into the second episode of the TV miniseries, in the scene where Nick Andros and Tom Collins meet Julie from the drug store, the boom mic is seen for several seconds at the bottom right of the screen after Julie crosses the street to meet them.
Visible crew/equipment: Near the end of the film after Depp leaves the castle after shooting Balkin and gets into his car you can see a crew member in the side view mirror as Depp opens and closes the driver side door.
Continuity mistake: Just before Steve Hadley is killed by the Merman, his tie is wrapped around his neck. When the Merman attacks him, his tie is worn properly. (01:19:40)