Plot hole: When Charlie looks up the file on David Esterbrook, he says that the file shows that Esterbrook is directly responsible for INtREPUS' "controversial" R&D, including pre-natal gene therapy, human/animal hybridization, and viral warfare. Yet later, Olivia says she can find no dirt on Esterbrook who is, in her words, "cleaner than snow". If INtREPUS kept records of their illegal endeavours, then how come Olivia can't find them when the time calls for it?
Plot hole: When interrogating Boone, Olivia shows him a photo of a body with the spine torn out in the woods. This body hasn't been found yet, as a later scene has Olivia and Peter go to the same location and find the body. You can tell it's the same body because the shirt is the same in both the picture and the crime scene.