Factual error: The main apartment in the show is located in Pasadena, Calif. When looking out the window in the background, mountains are shown in the distance and far away. In reality, Pasadena lies right underneath the long mountain range so the mountains would be up close, not far away.
Suggested correction: Not true. I lived in Pasadena for years and in some areas, the mountains do look further away. The view from the San Pasqual apartments, you can barely see the mountains.
Factual error: Every time we see Leonard's laser lab the door is open and he is able, if the story requires it, to fire the laser. As evidenced by the several safety notices visible and the scripted requirements for characters to put on safety goggles it should not be possible to activate the laser while the lab door is open - it would be interlocked, meaning the laser wouldn't function unless the door is closed.
Factual error: Characters sometimes talk to one another on video calls, and a character (A) often watches these from an angle rather than face on, allowing the viewer to see both character A and the character on the call (B). When this happens, character B is shown turned a little to one side, to give the impression that they are looking directly at character A (as they would be if they were present in the same room). In reality, this means that character B is looking off to one side of their monitor and not at the image of character A, something that it makes no sense to do. No matter what angle the laptop is shown from, provided character B is visible, they should appear to be facing the viewer.
Suggested correction: Since we almost always see these video calls using full-screen, people sitting side-by-side would be on different sides of the screen. You wouldn't look into the webcam itself to see them. You would look at the screen, and move your head slightly to look at the left part versus the right.