
The White Asparagus Triangulation - S2-E9
Continuity mistake: When Sheldon is in Penny's apartment trying to get her to tell him why her relationship with Leonard failed, the yellow tee-shirt on the red pillow next to him keeps changing position.
The White Asparagus Triangulation - S2-E9
Continuity mistake: When Sheldon, Raj and Howard are talking in the cafeteria, Sheldon's drink keeps moving position.

The White Asparagus Triangulation - S2-E9
Continuity mistake: When Leonard is helping Sheldon open the jar, the red napkin which he left on the couch where he was sitting changes position or vanishes in every shot.

The White Asparagus Triangulation - S2-E9
Continuity mistake: When Sheldon is questioning Raj and Howard in the cafeteria, the bottle of water is on Raj's tray faces the camera with the barcoded side. But in one closeup it rotates to show the logo-branded side.
The White Asparagus Triangulation - S2-E9
Continuity mistake: When climbing the stairs at the start, Penny and Sheldon turn the corner and carry on the conversation. Camera cuts and now they turn the corner again and continue their conversation without breaking it.
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.