Character mistake: When Catherine slams the trash can lid shut outside and heads to the car to answer her phone, she tells her Mum 'Catherine threw something out', referring to Lindsay.
Factual error: Dry ice sublimates at -78.5 C. That gas is going to be very, very cold and it will rapidly bring the temperature of the room down to a very uncomfortable level. Before a sleeping person suffocates they would be woken by the freezing cold.
Factual error: The murderer kills the two students by drilling a hole through the adjoining wall of the victim's room at floor level, placing 40lbs of dry ice next to the hole, and allowing the sublimating carbon dioxide to pass through the hole into the victim's room and creating a toxic atmosphere. Since the two rooms are at the same air pressure, the only possible way for the CO2 to move from one room to the next is to be pumped through. As neither room has an excessive level of carbon dioxide in the atmosphere the sublimating gas would fill both rooms until the CO2 levels in both rooms was the same.
Plot hole: The bodies were pink because of exposure to the lower temperatures created by the dry ice venting into the room. None of the CSI team noticed a chill when they entered the room? None of them noticed the bodies were cold to the touch? No one noticed that the body or liver temperatures didn't match with the estimated time of death?
Continuity mistake: In the opening scene, the female student is wearing green panties. When the two bodies are found, she is wearing red panties. It was a murder behind a locked door, so no one changed them for her.
Suggested correction: The girl had green panties with pink or red strings. When she was found, all that was visible was the string.
Visible crew/equipment: When David, Warrick and Catherine are standing in the crop circle discussing how the body ended up there, when David says "I have an idea", Warrick looks up slightly and you can see the boom mike reflected in his sunglasses.
Continuity mistake: Season 5, Episode "Grave Danger" (parts 1 and 2); there are a number of shots of Nick in the grave which don't match what the CSI team see via webcam. For example when he is speaking into the tape recorder he is holding it above his head from the view inside the grave, but from webcam he is holding it further down.
Continuity mistake: During the scene where Catherine goes to her father for the money to save Nick, the character played by Frank Gorshin is talking. At one point he is seen from the front and puts his hand up to fiddle with his collar/neck. The shot changes to a side view and both of his hands are suddenly in his lap with no time for him to have put his hands down.
Continuity mistake: When Grissom is on top of the box, talking to Nick, and he tells Nick to put their hands together, you can see that from shot to shot, the alignment of their hands changes. In one shot (from Nick's angle), Grissom's hand is higher than Nick's, as well as Grissom's index finger lines up with Nick's middle finger. In the next shot, their hands line up perfectly. The alignment changes throughout those few shots.
Continuity mistake: There are some major continuity errors in the rescue scene at the end: First, the loader is missing from the side of the grave during several of the shots. Second, the rope changes position. The CSI crew is shown manning the rope, which is running parallel to the ground, ready to pull Stokes out of the grave. (There is a physics problem with this anyway.) The next shot is a close up of Grissom and Brown and the rope is now going up at a severe angle. Brown can barely reach it. (The stuntman can only be pulled out from above, the aforementioned physics problem, and the rope is leading up to the rigging.) Third, immediately after the stuntman is pulled from the grave and right before the explosion, there is no one and nothing near the grave. The loader ends the scene right where it started: on the edge of the grave, bucket up, lights on.
Other mistake: There is no way a body can be pulled out of a grave the way they showed. It would be a pretty tough trick to pull off with a 6', 200lb piece of lumber and virtually impossible with a body. If it was a solid, non-flexible piece of material, pulling on the rope would drag the item until it hit a ledge and then flip it out of the grave. The body is very flexible, especially at the waist. You'd have to pull a body from above, which they end up doing in real life.