Factual error: According to the show, Angel learned quite a few languages when he was evil. However, when he tries to start a conversation with a red-faced demon, he makes terrible mistakes. He said "Hablo Espanol?" which literally means "Do I speak Spanish?" and he said something like "Are you from Byelorussia?" in a tongue that hardly resembled Russian, although according to the captions, it was said in Russian.
Factual error: Wesley has his throat cut, deeply enough to at least nick the artery (based on the amount of blood) and the windpipe (based on his difficulties breathing and talking later on), yet he somehow survives being left alone in the park for over 24 hours. In reality, he would have been dead long before then.
A New World - S3-E20
Factual error: Connor has been raised since he was a few months old by Holtz, a man with a British accent, in a dimension where there are no other humans. There is no possible way he could have an American accent, yet from the moment of his return he speaks with one.
Suggested correction: The demons in Pylea spoke English with American accents (possibly due to Wolfram and Hart's interference), and in tie-in comics, demons in the dimension Connor and Holtz went to were shown speaking regular English, though these comics were released years later.
Ground State - S4-E2
Factual error: In the flashback to Gwen as a child in 1985, she is dressed in a jacket tagged with an "Old Navy" zipper. That clothing store chain wasn't founded until 1994.
The Cautionary Tale Of Numero Cinco - S5-E6
Factual error: When the mysterious person hands Cinco the business card during the 50's flashback (in the restaurant where he is sitting waiting for business), it says "Wolfram & Hart, Attorney's at Law." Clearly, there should be no apostrophe in "Attorneys" in this context - not a mistake a professional law firm would make.
Power Play - S5-E21
Factual error: Spike suggests that Illyria and Drogyn play Crash Bandicoot. They appear to be playing on an original Xbox console. The episode was broadcast on May 12th 2004, meaning that the only Crash Bandicoot game they could possibly be playing would be The Wrath of Cortex which came out on April 5th 2002 in North America because every other Crash Bandicoot game that came out before that was only on the Sony PlayStation (with the exception of Crash Nitro Cart, but they're not playing that one). Both Illyria and Drogyn appear to be playing the game. However, The Wrath of Cortex was a single-player only game. They're not playing Crash Twinsanity (available for the Xbox) either as that didn't come out in North America until October 1st 2004 and it too was a single-player only game.