Visible crew/equipment: When Lt. Chang tells the candidates, "It's unfair that only one candidate from Relva will attend the Academy this year," there are two tape marks visible on the floor between Chang and Mordock. (00:49:00)
Revealing mistake: In the corridor, as Wesley faces the Zaldan, the hallway behind the scene is obviously a painting due to the shadow of the support on the edges.
Continuity mistake: On his way to the Farewell party, Picard is seen wearing his dress uniform, but no pips on it. There should be four.
Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73