Audio problem: When Langdon is in the Vatican archives for the second time and they are running out of oxygen, He uses the Swiss Guard's gun to shoot the glass. The problem being it takes roughly 0.8 seconds from the time the sound of the gun goes off to have any impact on the glass. He is no further than 5 metres from the glass, but still, this should be instantaneous.
Audio problem: When Langdon and the Swiss guard are in the file room out of oxygen, the guard presses the oxygen control screen nervously, and a "clac" sound is heard. The shot changes and he stops pressing the button, yet the previous clac-clac-clac is heard for a couple seconds.