Revealing mistake: When the blade cuts the trolley in half, the blade hits the top of the trolley but the metal frame of the trolley is to break in a perfect cut. (00:04:30)
Other mistake: As Chase pulls the tanker to a stop in Vegas, the engine revs once more before it's shut down, but the rain caps don't pop up as they should from the extra puff of exhaust. (00:54:50)
Other mistake: In order to use the vials that have either the T-virus or the anti-virus it has to be loaded into a special gun-like tool, similar to a caulking gun. A plunger is then set, and released with a trigger, again, like a caulking gun. The problem is that when the vials are seen, the caps on either end are solid, with no hint of an opening for the fluid to get out and into the body that it is being administered to.
Continuity mistake: When Dr. Isaacs is injecting a zombie with his domestication serum, the head restraint on the zombie disappears. (00:26:10)
Continuity mistake: When Dr.Isaacs is injecting a zombie with his domestication serum, he changes positions from being beside the zombie, to being on the opposite side of the table. (00:26:10)
Revealing mistake: After Carlos blows his truck up and Alice is breaking into the Umbrella compound there is a moment where her truck drives through the fire and one of the zombies following her throws his arms up to shield himself from the heat of the flames. The actor apparently got too close for his own comfort. (01:11:00)
