Revealing mistake: As Carlos is giving his final goodbyes to Claire you can see in the background automobiles driving down the freeway. Shouldn't these roads be empty rather than having what seems to be a thriving highway? (01:10:00)
Suggested correction: Not a single car in the background.
Deliberate mistake: During the scene where Carlos and L.J. are searching the motel, L.J. sees a zombie which turns out to be a reflection in a wall-length mirror. L.J. shoots, breaking the mirror and realizing his mistake. But, if he had been standing in front of the mirror as shown, he should have seen his own reflection standing there as well. This was done as an homage to a similar encounter in the original game. (00:24:20)
Continuity mistake: When Dr. Isaacs is injecting a zombie with his domestication serum, the head restraint on the zombie disappears. (00:26:10)
Continuity mistake: When Dr.Isaacs is injecting a zombie with his domestication serum, he changes positions from being beside the zombie, to being on the opposite side of the table. (00:26:10)