Plot hole: Lucy has been painting pictures of Henry since she moved into the institute. But she passes him at the zoo and doesn't recognize him.
50 First Dates (2004)
1 plot hole - chronological order
Directed by: Peter Segal
Starring: Adam Sandler, Drew Barrymore, Sean Astin, Rob Schneider
Continuity mistake: When Henry is leaving the dock, Alexa waves with her right hand. Notice the watch. When Alexa grabs some butt from Doug, The watch is now on left arm. (01:23:10)
Nick: Hey, Mr. Peanut Butter Cups.
Henry: Hey, Mr. Could-Kill-Me-In-One-Punch.
Trivia: When Henry (Adam Sandler) is at the golf course with Ula and his kids, everyone except Henry is teeing off in the same style as Happy Gilmore (also played by Sandler) in "Happy Gilmore" (1996). When Henry sees this, he replies, "That is the dumbest thing I have ever seen."
Question: What would happen if Lucy stayed up all night and she was with Henry? Would she all of a sudden forget him or would it happen very slowly?
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Chosen answer: Apparently, she loses all her daily memories when she enters a full sleep, so keeping her awake would have given them a chance to see each other for longer periods.
Joshua Skains
Then my question is what about the naps during the day that she takes?
Naps would reset her brain like any other sleep.