Deliberate mistake: Frequently during the movie, British surgeons are referred to as "Doctor". In Britain, surgeons are always referred to as "Mister"; this is a hold-over from the surgeon's non-medical past (barbers, etc). This would likely be confusing to American audiences.
From Hell (2001)
1 deliberate mistake - chronological order
Directed by: Albert Hughes, Allen Hughes
Starring: Johnny Depp, Ian Holm, Heather Graham, Robbie Coltrane
Factual error: Towards the end of the movie, Mary sends a hand-written note to Inspector Abberline. The 'r' in her name is written in a North American style, where she is European.
Sir William Gull: No man amongst you is fit to judge the mighty art that I have wrought. Your rituals are empty oaths you neither understand, nor live by. The Great Architect speaks to me. He is the balance where my deeds are weighed and judged, not you.
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Answer: His eyes are not just darker, his entire eyes are completely black. This was done by CGI effects to show that the murderous Ripper side to Gull's persona is taking over and is in control.
Twotall