Continuity mistake: The first time we see the young doctor doing his "lobotomy" in London Hospital (to the girl that was married to Prince Edward), Ian Holm comments on the procedure for some guest as they stand behind a glass window. You can clearly see the young doctor doing the third strike with his hammer in a reflection in the window. The movie cuts back to the young doctor and he is doing the third strike for a second time.
From Hell (2001)
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Directed by: Albert Hughes, Allen Hughes
Starring: Johnny Depp, Ian Holm, Heather Graham, Robbie Coltrane
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Sir William Gull: No man amongst you is fit to judge the mighty art that I have wrought. Your rituals are empty oaths you neither understand, nor live by. The Great Architect speaks to me. He is the balance where my deeds are weighed and judged, not you.
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Answer: His eyes are not just darker, his entire eyes are completely black. This was done by CGI effects to show that the murderous Ripper side to Gull's persona is taking over and is in control.
Twotall