Continuity mistake: The first time we see the young doctor doing his "lobotomy" in London Hospital (to the girl that was married to Prince Edward), Ian Holm comments on the procedure for some guest as they stand behind a glass window. You can clearly see the young doctor doing the third strike with his hammer in a reflection in the window. The movie cuts back to the young doctor and he is doing the third strike for a second time.
From Hell (2001)
Ending / spoiler
Directed by: Albert Hughes, Allen Hughes
Starring: Johnny Depp, Ian Holm, Heather Graham, Robbie Coltrane
Sir William Gull, the doctor of the Royal Family is Jack the Ripper. He has been killing the witnesses to Prince Eddy's (forbidden) Catholic marriage to a whore who bears his legitimate daughter (Alice), who is therefore the heir to the British throne. The Freemasons, a secret society of which Gull is a member, decide to lobotomize him as retribution for his unnecessarily violent and bloody solution to the Royal problem. Mary Kelly doesn't die. Jack mistakes Ada, the Belgian girl, for her and kills her instead. Mary lives happily ever after with Alice in a cottage on a cliff by the sea. Inspector Frederick Abberline dies alone, knowing he is being watched so can never see Mary again without endangering her.
More mistakes in From Hell
Jack the Ripper: I shall tell you where we are. We're in the darkest region of the human brain, a radiant abyss where men go to find themselves.
Netley: I don't understand, sir.
Jack the Ripper: Hell, Netley. We are in hell.
More questions & answers from From Hell
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Answer: His eyes are not just darker, his entire eyes are completely black. This was done by CGI effects to show that the murderous Ripper side to Gull's persona is taking over and is in control.
Twotall