Trivia: When the taxi Jessica and Eddie are in hits the lamppost, she spins around and her dress shifts position. For a couple of frames on the laserdisc version her underwear vanishes, or at least it appears to. Opinion is divided as to whether it's a deliberate move by the animators or just an error in colouring. (https://www.snopes.com/fact-check/who-stripped-jessica-rabbit/). (00:18:15)
Trivia: A nice subtle detail you might not notice right away - in almost every single scene, Doom's cloak is lightly billowing, as though it has a perpetual breeze running through it. Not only is this a cute nod to the classic cliche of the "billowing cloak" many villains have in comics and cartoons, but it's also a very subtle "hint" that something's not quite right about him.
Trivia: In a bit of irony, Bob Hoskin's live-action character Eddie Valiant had to be animated in a few quick shots during the car-chase with the weasels and Bennie the cab, due to the high-speeds and/or chaotic movement, which would have been too dangerous (or too impractical) to do with Bob Hoskins or a stunt-double. These shots (which actually look fairly creepy, due to Valiant's animated form falling into "uncanny valley") are most easily seen by going frame-by-frame in certain quick shots.
Trivia: While uncredited for the role, it's mostly known that Kathleen Turner did the voice for Jessica Rabbit. However, that was only for the speaking parts. Her singing voice was actually done by Steven Spielberg's then-wife, Amy Irving.
Answer: There's really a lot of possible reasons he hates other toons. There's a whole Roger Rabbit book and comic book series that explain Doom's background more. In the film, he's greedy and wants to destroy Toon Town to build the freeway to make more money. In human disguise he's also seen as merciless and is just punishing toons to maintain law and order, etc. Although that's just an excuse to kill toons as well. However, not explained in the film; as a toon he was cast as the antagonist in cartoon films until an accident one day left him thinking he was an actual villain (as opposed to just an actor playing one). That's when he began his life of crime, including killing Teddy Valiant. So his hatred of toons is more about him being evil and not a personal vendetta against them, like Blade's motives.