Continuity mistake: Between Wade stabbing Ajax to the bridge barrier and him talking to Colossus, the sun changes every shot.
Continuity mistake: When Deadpool comes back to the duplex after cutting off his own hand, he grabs a red towel off a Chevy Citation parked outside. When he enters and flops onto the floor, the towel is yellow.
Answer: No and I think that was the joke. He was angry at that whole system so taking out everyone who worked for Francis was probably just him warming up for Francis. What possibly proves this is when he finally gets to 'Agent Smith' he actually asks "where is your boss?" He doesn't say Francis to him.