Continuity mistake: At the end the blood around Francis' mouth keeps changing between shots - blood all over his teeth then not, then back.

Deadpool (2016)
Plot summary
Directed by: Tim Miller
Starring: Ryan Reynolds, T.J. Miller, Morena Baccarin, Gina Carano
Diagnosed with terminal cancer, a mercenary decides to take part in an experimental trial to activate latent mutant genes in the hope of finding a cure. Given superpowers but also horribly disfigured, he embarks on a wisecracking mission to find the man responsible while also protecting the woman he loves.
[Wade is using a bleach pen on his clothes to remove the blood]
Blind Al: Seltzer water and lemon for blood. Or wear red. Dumbass.
Trivia: In the 'happy Lent' scene, Wade is reading the Mario Lopez autobiography. Mario Lopez filmed a promotion with Ryan Reynolds where they pretended the movie was going to be toned down to a PG-13, which would have infuriated fans, before revealing the true R rating.
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Answer: Yes that would be how she most likely was able to tell.