Factual error: Samuel Clemens, who has written several humorous tales for the Territorial Enterprise, tells the publisher he would like to start writing serious news stories. The publisher replies, "This is a newspaper, not a comic strip. You write it and I'll print it." The first comic strip, "The Little Bears," debuted in 1893 and the term "comic strip" did not enter the vocabulary until 1920. "Bonanza" is set in the 1860s.
Continuity mistake: Little Joe is bitten on the right hand by a gypsy in a bedroom. He exits the room rubbing his left hand which is examined by Ben and Hoss. (00:07:00)
Continuity mistake: Halfway through the show, Ben is talking to the commanding officer and captain of a fort. Ben leaves the room and closes the door but the door swings back to being almost full open. The commander and captain talk about going to the Ponderosa with a warrant to check for deserters. When they walk to the door, it is closed.