The Grasshopper Experiment - S1-E8
Deliberate mistake: At the end, Penny holds up a bottle of rum to show Leonard that she added it to his drink. However, the B is missing from the name "Bacardi" (00:19:30)
The Big Bang Theory (2007)
1 deliberate mistake in season 1
Starring: Kaley Cuoco, Johnny Galecki, Melissa Rauch, Simon Helberg, Jim Parsons, Kunal Nayyar
Genres: Comedy
The Countdown Reflection - S5-E24
Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
The Staircase Implementation - S3-E22
Leonard: Oh, screw the roommate agreement!
Sheldon: No, you don't screw the roommate agreement! The roommate agreement screws you!
The Fish Guts Displacement - S6-E10
Trivia: In the beginning, after talking about the Spider-Man theme, Sheldon says it's right up there after Inspector Gadget and Teenage Mutant Ninja Turtles (to which the gang chimes in "heroes in a half shell, turtle power"). Chuck Lorre, the show's creator, wrote the original TMNT theme song that they are referring to.
The Euclid Alternative - S2-E5
Question: Though it comes up in other episodes as well, this one is focused on Sheldon needing a ride everywhere he goes because he can't drive, not to mention his not being welcome on the bus. Of course, this story element would be nonexistent if there was a simple answer, but it does beg the question: Does Pasadena not have taxicabs?
Answer: Sheldon DID finally use a taxi when going to the airport to see and propose to Amy in New Jersey.
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Chosen answer: It does. The variable cleanliness of the cab and the habit of taxi drivers to engage customers in small talk would be too much for Sheldon to handle, and not an option for him.
Captain Defenestrator