Starring: Kaley Cuoco, Johnny Galecki, Melissa Rauch, Simon Helberg, Jim Parsons, Kunal Nayyar
Genres: Comedy
The Large Hadron Collision - S3-E15
Factual error: At the very end of the show, Leonard and Raj arrive at the hotel, which is supposed to be in Geneva, Switzerland, to visit CERN. If you look out the "hotel" window, it looks like they're half way up Matterhorn, but in Geneva there are no big/rocky mountains anywhere near the city itself.
The Countdown Reflection - S5-E24
Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
The Big Bran Hypothesis - S1-E2
Sheldon: Oh Gravity, thou art a heartless bitch.
The Fish Guts Displacement - S6-E10
Trivia: In the beginning, after talking about the Spider-Man theme, Sheldon says it's right up there after Inspector Gadget and Teenage Mutant Ninja Turtles (to which the gang chimes in "heroes in a half shell, turtle power"). Chuck Lorre, the show's creator, wrote the original TMNT theme song that they are referring to.
The Euclid Alternative - S2-E5
Question: Though it comes up in other episodes as well, this one is focused on Sheldon needing a ride everywhere he goes because he can't drive, not to mention his not being welcome on the bus. Of course, this story element would be nonexistent if there was a simple answer, but it does beg the question: Does Pasadena not have taxicabs?