Character mistake: At the very beginning of the episode Leonard says "So you see what you're eating is not technically yogurt because it doesn't have enough live active acidophilus cultures." He is implying this is a scientific fact (he's not just giving his opinion on yogurt.) But to meet the U.S. standards for yogurt, only the starter cultures Lactobacillus bulgaricus and Streptococcus thermophilus are required, not Lactobacillus acidophilus. The presence or absence of L. acidophilus does NOT determine a food's identity as yogurt (which Leonard's line is implying). (00:00:05)

The Big Bang Theory (2007)
1 character mistake in The Bad Fish Paradigm
Starring: Kaley Cuoco, Johnny Galecki, Melissa Rauch, Simon Helberg, Jim Parsons, Kunal Nayyar
Genres: Comedy
The Countdown Reflection - S5-E24
Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
The Extract Obliteration - S6-E6
Stephen Hawking: Do you like brain teasers?
Sheldon Cooper: Oh, I love brain teasers.
Stephen Hawking: What do Sheldon Cooper and a black hole have in common? They both suck. Neener, neener.
The Work Song Nanocluster - S2-E18
Trivia: After Sheldon mentions a molecular sieve, they go over to 4a, their apartment. 4a is a kind of molecular sieve.
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Chosen answer: The song is called "Dark as a Dungeon" and was written and first performed by singer-songwriter Merle Travis in 1946. It has been performed by a wide array of artists, including Tennessee Ernie Ford, Harry Belafonte, Dolly Parton, Queens of the Stone Age, Kathy Mattea and Amy Grant. But it was made most famous when it was performed and recorded by Johnny Cash during his concert at Folsom Prison in 1968. According to Wikipedia: "It is a lament about the danger and drudgery of being a coal miner in an Appalachian shaft mine. It has become a rallying song among miners seeking improved working conditions."
Michael Albert