Continuity mistake: Just before George withdraws some blood from Bex's arm, her right sleeve is rolled up when Addison is beside her talking. In the next shot as Bex is drawing, the sleeve is suddenly rolled back down and George pulls it back up again to get some blood.
Owner of a Lonely Heart - S2-E11
Continuity mistake: When Dr. O'Malley is talking with Carl Murphy in his room, the position of the circle of containers (with the leeches inside them) changes between the shots during the scene. (00:32:10)
Owner of a Lonely Heart - S2-E11
Visible crew/equipment: When Burke hands Cristina the cup of coffee as she leaves for the hospital, blue screens can be seen in his eyeglasses.
Thanks for the Memories - S2-E9
Continuity mistake: When Holden is talking to Meredith about whether he wants the surgery or not, his hand is on this chest, then isn't, then is again. (00:28:10)
Continuity mistake: When Alex and George are trying to get out of the elevator that they are stuck in, watch the monitor screen attached to the gunshot victim. The lines on the monitor keep instantly changing appearance (from straight, to jagged, and then back, etc.), especially the middle blue line. (00:13:05)
Continuity mistake: When Meredith, Christina and Izzy are standing by the hospital hall balcony talking, the nurse, doctor and patient extras walking and passing in the background are inconsistent from shot to shot. In addition, the position of the three ladies arms / hands on the banister keeps changing during this scene. (00:12:35)
Continuity mistake: When Alex walks over to the desk that Derek is sitting behind, with the couple arguing in the background, there is a box of tissues with a tissue pulled so that it is almost out. In the next shot the tissue is barely out of the box. (00:26:20)
Visible crew/equipment: After Meredith discovers Derek visiting her mother at the nursing home, when it cuts to Miranda in the OR the T-mark can be seen on the floor at Cristina's feet. (00:26:40)
Owner of a Lonely Heart - S2-E11
Visible crew/equipment: In the NICU, when George starts boasting that he has the best quint, in the overhead wideshot we can see the T-mark (greenish yellow) on the floor near Kate, moments before Karev walks in and stands there. It's visible again just as Karev walks away. (00:01:05)
17 Seconds - S2-E26
Visible crew/equipment: After Burke and Alex board the helicopter to get the heart transplant, in the shot of Cristina backing away from it, you can see a red-capped crewmember and the camera reflected in the chopper's window. (00:06:25)
Continuity mistake: When Addison gives Derek the juju cocoa, he raises it to his lips three times in different shots, then is instantly holding it down by his waist in the next. (00:04:00)
Continuity mistake: When Izzie is looking at the patient board, there are some lines on it which have been wiped out. But in the next scene we actually see Meredith walk to the board and wipe these exact same lines off (even though they were previously rubbed out...) (00:34:05)
Band Aid Covers the Bullet Hole - S2-E21
Continuity mistake: When Callie places the hockey player's hand X-Ray on the chart, in the first shot it is on the left of the board. In the next it is dead centre and then back to being on the left again. (00:09:35)
(As We Know It) (Part II) - S2-E18
Continuity mistake: After Alex and Izzie have had sex in the closet, just before Izzie leaves in the first shot her hair is hanging in front of her shoulders. In the next shot as she walks out, it is all pulled back behind them. (00:13:35)
Continuity mistake: When Derek gives Meredith a white bag to hyperventilate into when she is crying in the closet, the large orange sticker on the side of the bag disappears and then reappears again. (00:35:30)
Continuity mistake: At the beginning when Derek is going to cook the trout and Addison is angry at him, the fridge door is shut. But in the next shot it is open a little bit and Derek closes it. (00:02:20)
Grandma Got Run Over By A Reindeer - S2-E12
Visible crew/equipment: When Burke and Cristina are walking along and Burke asks her if there is anything he should know about her religious holidays, you can see crewmembers, a boom and a stage light reflected in the glass running alongside. (00:05:30)
Grandma Got Run Over By A Reindeer - S2-E12
Continuity mistake: Derek is talking to Addison while he takes his iPod, winds the earphones around it and puts it in his pocket. But then as he stands, the iPod is now clipped to his shirt and the earphones are hanging around his neck! (00:26:00)