Continuity mistake: When Miles jumps off the ferry to swim ashore, the camera view is from the ferry: he jumps into quiet, fairly level water, yet the camera recedes from him (he jumped off the back of the boat as the camera continues moving with the boat). The angle changes and we see the wake of the boat - but it's not what he jumped into.
Other mistake: Laura is in the security control room of the plant, and finds a Master Lock Console screen; she sees it has Biometric Scan access and comments to Rich "It's not a retina scanner. It works on biometrics." She then brings up a photo ID of an employee on the monitor, lifts up the scanner and places it against the monitor, to get access. Firstly, retinal scans ARE biometric. She should have said "It's not an iris scanner," which requires a physical eyeball to scan. Secondly, no monitor from the 2005 period would be high-resolution enough to fool a biometric scanner. (00:25:20)
Factual error: Laura gets in the elevator to find Rich; she tells him on the phone there are 12 lower levels to choose from (that is, 12 basement floors to choose from) - but there are only 6 buttons in total on the control pad. (00:23:15)
Continuity mistake: When Rich is held captive in the locked room, he looks out and sees the "Countdown to Landfall" counter at 19min, 51sec. A few minutes later (in plot time), a scientist is seen saying they're now "23 minutes out." (00:11:25 - 00:12:30)
Factual error: When Rich and Laura are checking the US Patent Office records for the Nortide drug, the date of the patent is shown as "December 22th, 1963." The form is a modern, barcoded typed document, not a hand-written or typed one, and supposedly a formal US government document, so the '22th' should not have happened. (00:15:45)
Factual error: When Rich and Laura are searching for drug information from the 1960s, they visit the US Patent Office website; under the heading "SSRIs", is displayed "Selecttive Serotonin Reuptake Inhibitors" - with the double-t spelling error. (00:15:25)