Mr. Monk and the Astronaut - S4-E14
Plot hole: There is no drug in the world that could render a healthy adult unconscious for two days with a single dose, but let's go with the dramatic licence and allow that there is. Any such drug would be instantly detectable in any one of a dozen toxin screens carried out during an autopsy, and isn't someone going to wonder how a comatose woman hanged herself?
Mr. Monk and the Astronaut - S4-E14
Plot hole: The whole plot hinges on Steve Wagner knocking the victim out for 2 days, remotely hanging her while he's in space, then removing the hanging machine when he lands. But keeping someone unconscious chemically for 2 DAYS is a hell of a feat. And unpleasant though it is, she'd be voiding her bowels over those 2 days, leaving a serious mess, plus all the chemicals necessary to keep her unconscious would be found in an autopsy.
Mr. Monk and the Astronaut - S4-E14
Plot hole: The murderer mails a garage door opener with the button taped down to his victim and kills her by remote. But A) With the switch continuously in the "on" position, the battery would die long before the package arrived, and B) Door openers use special frequency tones that are set much like a safe combination. The likelihood of one control opening 3 different doors in the same area, as it does here, is virtually nil. (00:33:30)
Answer: Notice also that in the opening credits scene when he is touching parking meters her also wipes his hand on his clothes each time he does it.