Phoenix (2) - S3-E2
Plot hole: When Edge needs the vial of Clark's blood back, Edge holds Clark's parents hostage. Clark decides to use a sharp piece of kryptonite rock to cut his skin and give Edge a new sample. When Clark picks it up, and when he places the kryptonite rock on his skin, he shows no sign of the usual effects of the rock which include the green lines radiating up his arms.
Answer: In the comics, Krypto is a dog from Krypton who was used as the passenger in a test launch by Jor-El, Superman's father, before he launched the actual rocket taking his infant son to Earth. Krypto's capsule was involved in a mishap, sending it out of Kryptonian orbit and eventually found its way to Earth where he linked up with the young Clark Kent. Like any native of Krypton, Krypto has superpowers on Earth. In Smallville, the dog is a standard Earth dog who has been experimentally injected with kryptonite, giving him super-strength for a limited period of time, who escapes and links up with Clark (who suggests the name Krypto, ostensibly because of the dog's cryptic origins). It doesn't take too long for the dog's strength to fade, and the Kents decide to keep him, although they ultimately name him Shelby, after a dog that Martha Kent had in childhood.
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